Background: A series of Triazine Chalcone derivatives were synthesized by the condensation
of 1-(4-((4,6-dimethoxy-1,3,5-triazin-2-yl)amino)phenyl)ethanone with substituted benzaldehyde
in methanol solvent.
Methods: All the synthesized derivatives (3a-l) were screened for their anti-bacterial evaluation
against Gram negative bacteria Escherichia coli (NCIM 2137) and Pseudomonas aeruginosa
(NCIM 2036); Gram positive bacteria Staphylococcus aureus, Bacillus subtilis (NCIM 2250) and
four fungal stains. Candida albicans (MTCC 227), Aspergillus niger (NCIM 545), Candida tropicalis
(NCIM 3110) and Candida glabrata (NCIM 3236).
Results and Conclusion: Several target molecules throughout the series showed good antibacterial
and antifungal activity against tested stains.
Keywords: Antibacterial, antifungal, antimicrobial activity, Benzaldehyde, Chalcone, 4, 6-dimethoxy-N-phenyl-1, 3, 5-triazin-2-
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