Design, Synthesis and Antimicrobial Activity of Some Triazine Chalcone Derivatives

(E-pub Ahead of Print)

Author(s): Ravindra Sandipan Shinde*, Satish Ashruba Dake, Rajendra Pundalikrao Pawar

Journal Name: Anti-Infective Agents
Anti-Infective Agents in Medicinal Chemistry

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A series of Triazine Chalcone derivatives were synthesized by the condensation of 1-(4- ((4,6-dimethoxy-1,3,5-triazin-2-yl)amino)phenyl)ethanone with substituted benzaldehyde in methanol solvent. All the synthesized derivatives (3a-l) were screened for their anti-bacterial evaluation against Gram negative bacteria Escherichia coli (NCIM 2137) and Pseudomonas aeruginosa (NCIM 2036); Gram positive bacteria Staphylococcus aureus, Bacillus subtilis (NCIM 2250) and four fungal stains. Candida albicans (MTCC 227), Aspergillusniger (NCIM 545), Candida tropicalis (NCIM 3110) and Candida glabrata (NCIM 3236). Several target molecules throughout the series showed good antibacterial and antifungal activity against tested stains.

Keywords: Antibacterial, Antifungal, Benzaldehyde, 4, 6-dimethoxy-N-phenyl-1, 3, 5-triazin-2-amine, Chalcone

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(E-pub Ahead of Print)
DOI: 10.2174/2211352517666190710115111