Synthesis and Anti Cervical Cancer Activity of Novel 5H-Thiochromeno [4,3-d]pyrimidines

Author(s): Dhananjay Pandya, Yogesh Naliapara*.

Journal Name: Letters in Organic Chemistry

Volume 17 , Issue 4 , 2020

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Abstract:

A series of novel 5H-Thiochromeno[4,3-d]pyrimidine derivatives were synthesized, purified and characterized by different spectroscopy techniques such as 1H NMR, 13C NMR, Mass and Elemental Analysis. The new compounds were evaluated for their anti-cervical cancer activity on Human Cervical Cell Line HeLa. They were found to be potent anti-cervical cancer agents with GI50 values less than 10 μg/mL with respect to positive control drug Adriamycin.

Keywords: 5H-Thiochromeno[4, 3-d]pyrimidine, benzothiopyranopyrimidine, anti-cervical cancer activity, adriamycin, human cervical cancer cell line HeLa. Spectroscopy, elemental analysis.

[1]
Bruno, O.; Brullo, C.; Schenone, S.; Bondavalli, F.; Ranise, A.; Tognolini, M.; Impicciatore, M.; Ballabeni, V.; Barocelli, E. Bioorg. Med. Chem., 2006, 14(1), 121-130.
[http://dx.doi.org/10.1016/j.bmc.2005.07.066] [PMID: 16154749]
[2]
Marini, A.; Settimo, F.; Salerno, S.; Motta, C.; Simorini, F.; Taliani, S.; Bertini, D.; Gia, O.; Dalla, L. Heterocyclic Chem., 2008, 45, 745.
[3]
Chu, S.; Chyan, W.; Chang, C. Huaxue Xuebao, 1956, 22, 371.
[4]
Primofiore, G.; Marini, A.; Settimo, F.; Salerno, S.; Bertini, D.; Dalla, L.; Marcianimagno, S. J. Heterocycl. Chem., 2003, 40, 783.
[5]
Fravolini, A.; Martani, A.; Grandolini, G. Bollettino Scientificodella Facoltà di Chimica Industriale di Bologna, 1968, 26, 269.
[6]
Salerno, S.; Marini, A.M.; Fornaciari, G.; Simorini, F.; La Motta, C.; Taliani, S.; Sartini, S.; Da Settimo, F.; García-Argáez, A.N.; Gia, O.; Cosconati, S.; Novellino, E.; D’Ocon, P.; Fioravanti, A.; Orlandi, P.; Bocci, G.; Dalla Via, L. Eur. J. Med. Chem., 2015, 103, 29-43.
[http://dx.doi.org/10.1016/j.ejmech.2015.08.027] [PMID: 26318056]
[7]
Vichai, V.; Kirtikara, K. Sulforhodamine B colorimetric assay for cytotoxicity screening. Nat. Protoc., 2006, 1(3), 1112-1116.
[http://dx.doi.org/10.1038/nprot.2006.179] [PMID: 17406391]
[8]
Skehn, P.; Storeng, R.; Scudiero, A.; Monks, J.; McMohan, D.; Vistica, D.; Jonathan, T.; Bokesch, H.; Kenney, S.; Boyd, M. J. Natl. Cancer Inst., 1990, 82, 1107.
[http://dx.doi.org/10.1093/jnci/82.13.1107] [PMID: 2359136]


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Article Details

VOLUME: 17
ISSUE: 4
Year: 2020
Page: [294 - 302]
Pages: 9
DOI: 10.2174/1570178616666190705152116
Price: $65

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