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Current Protein & Peptide Science

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ISSN (Print): 1389-2037
ISSN (Online): 1875-5550

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Review Article

ATP-Diphosphohydrolases in Parasites: Localization, Functions and Recent Developments in Drug Discovery

Author(s): Lara Soares Aleixo de Carvalho, Ismael José Alves Junior, Lauriene Ricardo Junqueira, Lívia Mara Silva, Lorena Rodrigues Riani, Priscila de Faria Pinto and Ademar Alves Da Silva Filho*

Volume 20, Issue 9, 2019

Page: [873 - 884] Pages: 12

DOI: 10.2174/1389203720666190704152827

Price: $65

Abstract

ATP-diphosphohydrolases (EC 3.6.1.5), also known as ATPDases, NTPases, NTPDases, EATPases or apyrases, are enzymes that hydrolyze a variety of nucleoside tri- and diphosphates to their respective nucleosides, being their activities dependent on the presence of divalent cations, such as calcium and magnesium. Recently, ATP-diphosphohydrolases were identified on the surface of several parasites, such as Trypanosoma sp, Leishmania sp and Schistosoma sp. In parasites, the activity of ATPdiphosphohydrolases has been associated with the purine recuperation and/or as a protective mechanism against the host organism under conditions that involve ATP or ADP, such as immune responses and platelet activation. These proteins have been suggested as possible targets for the development of new antiparasitic drugs. In this review, we will comprehensively address the main aspects of the location and function of ATP-diphosphohydrolase in parasites. Also, we performed a detailed research in scientific database of recent developments in new natural and synthetic inhibitors of the ATPdiphosphohydrolases in parasites.

Keywords: ATP-diphosphohydrolase, apyrase, parasite, ATPDases, inhibitors, NTPDase, ecto-nucleotidases.

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