Background: Over the past few decades, nanotechnology has dramatically advanced;
from the precise strategies of synthesizing modern nanostructures to methods of entry into the body.
Using nanotechnology in diagnosis, drug delivery, determining signaling pathways, and tissue
engineering is great hope for the treatment of stroke. The drug-carrying nanoparticles are a way to
increase drug absorption through the mouth or nose in treating the stroke.
Objective: In this article, in addition to explaining pros and cons of oral and intra-nasal
administration of nanoparticles in the brain ischemia treatment of animal models, the researchers
introduce some articles in this field and briefly mentioned their work outcomes.
Methods: A number of relevant published articles 183 were initially collected from three popular
databases including PubMed, Google Scholar, and Scopus. The articles not closely related to the
main purpose of the present work were removed from the study process. The present data set finally
included 125 published articles.
Results: Direct delivery of the drug to the animal brain through the mouth and nose has more
therapeutic effects than systemic delivery of drugs. The strategy of adding drugs to the nanoparticles
complex can potentially improve the direct delivery of drugs to the CNS.
Conclusion: Despite the limitations of oral and intra-nasal routes, the therapeutic potential of oral
and intra-nasal administration of nano-medicines is high in cerebral ischemia treatment.