Differentiation from RAW264.7 cells to osteoclasts rely on many signaling pathways, such
as NF-κB, MAPK, Akt and others. However, the specific underlying mechanisms are not clear. Recently,
much works have focused on the inhibitory effects of plant derived compounds in the differentiation
from RAW264.7 to osteoclasts. However, the specific mechanisms remain unclear. In this paper,
we summarize a lot of plant derived compounds which exert blocking effect on the progression of
differentiation via signaling pathways.
Keywords: Plant derived compounds, osteoclasts, RAW264.7, signaling pathways, bone homeostasis, macrophage.
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