Overview of Molecular Mechanisms Involved in Herbal Compounds for Inhibiting Osteoclastogenesis from Macrophage Linage RAW264.7

Author(s): Gaole He, Rui Ma*

Journal Name: Current Stem Cell Research & Therapy

Volume 15 , Issue 7 , 2020

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Differentiation from RAW264.7 cells to osteoclasts rely on many signaling pathways, such as NF-κB, MAPK, Akt and others. However, the specific underlying mechanisms are not clear. Recently, much works have focused on the inhibitory effects of plant derived compounds in the differentiation from RAW264.7 to osteoclasts. However, the specific mechanisms remain unclear. In this paper, we summarize a lot of plant derived compounds which exert blocking effect on the progression of differentiation via signaling pathways.

Keywords: Plant derived compounds, osteoclasts, RAW264.7, signaling pathways, bone homeostasis, macrophage.

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Article Details

Year: 2020
Page: [570 - 578]
Pages: 9
DOI: 10.2174/1574888X14666190703144917
Price: $65

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