Background: Non-Hodgkin's lymphomas (NHL), derived from B- or T-cell, consist of a heterogeneous
group of malignant lymphoproliferative disorders. Knockdown of Casein kinase 2 interacting
protein-1 (CKIP-1) in NHL promoted cell proliferation and inhibited apoptosis via enhancing phosphorylated
Protein Kinase B (PKB or AKT) expression. Statins are the class of drugs that inhibit the ratelimiting
step of the mevalonate pathway, which is essential for the biosynthesis of various compounds, including
cholesterol. Also, statins have anticancer properties being mediated by different mechanisms.
Methods: A search on databases like Scopus and PubMed with keywords such as statin and non-
Hodgkin's lymphomas was performed and Kyoto Encyclopedia of Genes and Genomes (KEGG) website
was used to evaluate and reconfirm the involved cellular signaling pathway.
Results: CKIP-1 is involved in the regulation of cell proliferation and apoptosis while plays an important
role in many cancers. We can hypothesize that statins may increase the expression levels of CKIP-1 which
could contribute to the reductions in phospho-AKT level. Hence, they may ameliorate the NHL patients
via suppressing AKT phosphorylation and increasing CKIP- expression.
Conclusion: Present review confirms the positive effect of statins on NHL by increasing CKIP-1 and reducing
cell proliferation, subsequently.