Background: Increased oxidative stress has been reported in autistic patients besides,
evidence linking oxidative stress to enhancement of advanced glycation and lipoxidation end products
(AGEs and ALEs) and their precursors.
Objective: This study aimed to compare the plasma levels of the AGEs and precursors of ALEs in
autistic and healthy children and to evaluate their relationship with autism comorbidities.
Methods: In this descriptive study, 54 children, 36 autistic and 18 healthy participated. Plasma levels
of AGEs and precursors of ALEs were measured by ELISA method. Severity of autism and
Gastrointestinal (GI) disorders were measured by GARSII questionnaire and QPGS-ROME III
Results: Plasma levels of AGEs and precursors of ALEs in autistic children were comparable with
healthy children. Plasma levels of AGEs and precursor of ALEs were correlated with physical activity
and GI disorders in autistic children. A strong association was also found between AGEs and
precursors of ALEs.
Conclusion: The results indicate that AGEs and ALEs have a strong correlation together but the
AGEs and precursor of ALEs in autistic children are not different from healthy children.