Title:Synthesis, Biological Evaluation and Molecular Docking Study of Pyrazole, Pyrazoline Clubbed Pyridine as Potential Antimicrobial Agents
VOLUME: 18 ISSUE: 3
Author(s):Nisheeth C. Desai*, Darshita V. Vaja, Krunalsinh A. Jadeja, Surbhi B. Joshi and Vijay M. Khedkar
Affiliation:Division of Medicinal Chemistry, Department of Chemistry, (UGC NON-SAP & DST-FIST Sponsored), Maharaja Krishnakumarsinhji Bhavnagar University, Mahatma Gandhi Campus, Bhavnagar 364002, Division of Medicinal Chemistry, Department of Chemistry, (UGC NON-SAP & DST-FIST Sponsored), Maharaja Krishnakumarsinhji Bhavnagar University, Mahatma Gandhi Campus, Bhavnagar 364002, Division of Medicinal Chemistry, Department of Chemistry, (UGC NON-SAP & DST-FIST Sponsored), Maharaja Krishnakumarsinhji Bhavnagar University, Mahatma Gandhi Campus, Bhavnagar 364002, Division of Medicinal Chemistry, Department of Chemistry, (UGC NON-SAP & DST-FIST Sponsored), Maharaja Krishnakumarsinhji Bhavnagar University, Mahatma Gandhi Campus, Bhavnagar 364002, Department of Pharmaceutical Chemistry, Shri Vile Parle Kelavani Mandal's Institute of Pharmacy, Mumbai - Agra National Hwy, Dhule, Maharashtra 424001
Keywords:Pyrazole, pyrazoline, pyridine, heterocycles, antimicrobial activity, molecular docking.
Abstract:
Introduction: In continuation of our efforts to find new antimicrobials, herein we report
the synthesis of various pyrazole, pyrazoline, and pyridine based novel bioactive heterocycles (3a-t).
Methods: Newly synthesized compounds were analysed for their antimicrobial activity. Compounds
3c, 3h, 3i, 3k, 3n, and 3q showed significant antimicrobial activity.
Results: Molecular docking study for the most active analogues against DNA gyrase subunit b
(PDB ID: 1KZN) corroborated well with the observed antimicrobial potency exhibiting significant
binding affinity.
Conslusion: Interpretation of the chemical structures reported in this paper was based on IR, 1H
NMR, 13C NMR, and mass spectral data.
