Synthesis, Biological Evaluation and Molecular Docking Study of Pyrazole, Pyrazoline Clubbed Pyridine as Potential Antimicrobial Agents

Author(s): Nisheeth C. Desai*, Darshita V. Vaja, Krunalsinh A. Jadeja, Surbhi B. Joshi, Vijay M. Khedkar

Journal Name: Anti-Infective Agents
(Formerly Anti-Infective Agents in Medicinal Chemistry)

Volume 18 , Issue 3 , 2020

DOI : 10.2174/2211352517666190627144315

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Graphical Abstract:


Abstract:

Introduction: In continuation of our efforts to find new antimicrobials, herein we report the synthesis of various pyrazole, pyrazoline, and pyridine based novel bioactive heterocycles (3a-t).

Methods: Newly synthesized compounds were analysed for their antimicrobial activity. Compounds 3c, 3h, 3i, 3k, 3n, and 3q showed significant antimicrobial activity.

Results: Molecular docking study for the most active analogues against DNA gyrase subunit b (PDB ID: 1KZN) corroborated well with the observed antimicrobial potency exhibiting significant binding affinity.

Conslusion: Interpretation of the chemical structures reported in this paper was based on IR, 1H NMR, 13C NMR, and mass spectral data.

Keywords: Pyrazole, pyrazoline, pyridine, heterocycles, antimicrobial activity, molecular docking.

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Article Details

VOLUME: 18
ISSUE: 3
Year: 2020
Published on: 11 September, 2020
Page: [306 - 314]
Pages: 9
DOI: 10.2174/2211352517666190627144315

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