Introduction: In continuation of our efforts to find new antimicrobials, herein we report
the synthesis of various pyrazole, pyrazoline, and pyridine based novel bioactive heterocycles (3a-t).
Methods: Newly synthesized compounds were analysed for their antimicrobial activity. Compounds
3c, 3h, 3i, 3k, 3n, and 3q showed significant antimicrobial activity.
Results: Molecular docking study for the most active analogues against DNA gyrase subunit b
(PDB ID: 1KZN) corroborated well with the observed antimicrobial potency exhibiting significant
Conslusion: Interpretation of the chemical structures reported in this paper was based on IR, 1H
NMR, 13C NMR, and mass spectral data.