Aims: The foliar residues of Mangiferaindica tree are usually burned or used for soil
amelioration except nominal uses as fodder.
Methods: To add value to this agricultural waste, extracts of the leafy residues of M. indica were
studied to analyze their potential as antioxidants and to inhibit the enzymes related to the management
of diabetes, Alzheimer’s Disease (AD), hepatic disorders as well as to identify important phytochemicals
present in the extracts.
Results: Results depicts that the leaves have notable bioactivities. The methanol extract (ME)
showed much potential than ethyl acetate fraction after hydrolysis (HME) against α-amylase and α-
glucosidase. The activity against the enzyme β-glucuronidase was also higher than that of the commercial
β- glucuronidase inhibitor. The extract after hydrolysis showed better antioxidant and acetylcholinesterase
inhibitory activities. Detection of important phytochemicals such as chrysin and
myricetn, alizarin, arbutin, hydroquinone, tyrosol, taxifolin, kaempferol, mangiferin, and the vitamin
alpha tocophereol, in addition to a number of organic acids, amino acids, fatty acids, sugars and
polyols by GC-MS and HPTLC based analysis of the extract of M. indica leaf, also suggest the use
of the leaves as sources of these important phytochemicals.
Conclusion: More concisely HME with more number of detected metabolites found better to be
used against oxidative stress as well as enzymes related to neural and liver disorders than that of