Psoralen Derivatives: Recent Advances of Synthetic Strategy and Pharmacological Properties

Author(s): Joazaizulfazli Jamalis*, Faten Syahira Mohamed Yusof, Subhash Chander, Roswanira Abd. Wahab, Deepak P. Bhagwat, Murugesan Sankaranarayanan, Faisal Almalki, Taibi Ben Hadda*

Journal Name: Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry
Formerly Current Medicinal Chemistry - Anti-Inflammatory & Anti-Allergy Agents

Volume 19 , Issue 3 , 2020


DOI : 10.2174/1871523018666190625170802

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Graphical Abstract:


Abstract:

Psoralen or furocoumarin is a linear three ring heterocyclic compound. Psoralens are planar, tricyclic compounds, consisting of a furan ring fused to a coumarin moiety. Psoralen has been known for a wide spectrum of biological activities, spanning from cytotoxic, photosensitizing, insecticidal, antibacterial to antifungal effect. Thus, several structural changes were introduced to explore the role of specific positions with respect to the biological activity. Convenient approaches utilized for the synthesis of psoralen skeleton can be categorized into two parts: (i) the preparation of the tricyclic ring system from resorcinol, (ii) the exocyclic modification of the intact ring system. Furthermore, although psoralens have been used in diverse ways, we mainly focus in this work on their clinical utility for the treatment of psioraisis, vitiligo and skin-related disorder.

Keywords: Biological activity, chemotherapeutic agents, furan ring, heterocyclic compound, pharmacological properties, psoralen derivatives.

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Article Details

VOLUME: 19
ISSUE: 3
Year: 2020
Published on: 02 September, 2020
Page: [222 - 239]
Pages: 18
DOI: 10.2174/1871523018666190625170802

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