Title:Psoralen Derivatives: Recent Advances of Synthetic Strategy and Pharmacological Properties
VOLUME: 19 ISSUE: 3
Author(s):Joazaizulfazli Jamalis*, Faten Syahira Mohamed Yusof, Subhash Chander, Roswanira Abd. Wahab, Deepak P. Bhagwat, Murugesan Sankaranarayanan, Faisal Almalki and Taibi Ben Hadda*
Affiliation:Department of Chemistry, Faculty of Science, Universiti Teknologi Malaysia, 81310 Johor Bahru, Johor, Department of Chemistry, Faculty of Science, Universiti Teknologi Malaysia, 81310 Johor Bahru, Johor, School of Pharmacy, Maharaja Agrasen University, Atal Shiksha Kunj, Village Kalujhanda, Solan-174103, Himachal Pradesh, Department of Chemistry, Faculty of Science, Universiti Teknologi Malaysia, 81310 Johor Bahru, Johor, School of Pharmacy, Maharaja Agrasen University, Atal Shiksha Kunj, Village Kalujhanda, Solan-174103, Himachal Pradesh, Medicinal Chemistry Research Laboratory, Department of Pharmacy, Birla Institute of Technology & Science Pilani, Pilani Campus, Pilani- 333031, Rajasthan, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Umm Al-Qura University, Makkah Almukkarramah, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Umm Al-Qura University, Makkah Almukkarramah
Keywords:Biological activity, chemotherapeutic agents, furan ring, heterocyclic compound, pharmacological
properties, psoralen derivatives.
Abstract:Psoralen or furocoumarin is a linear three ring heterocyclic compound. Psoralens
are planar, tricyclic compounds, consisting of a furan ring fused to a coumarin moiety.
Psoralen has been known for a wide spectrum of biological activities, spanning from cytotoxic,
photosensitizing, insecticidal, antibacterial to antifungal effect. Thus, several structural
changes were introduced to explore the role of specific positions with respect to the
biological activity. Convenient approaches utilized for the synthesis of psoralen skeleton
can be categorized into two parts: (i) the preparation of the tricyclic ring system from resorcinol,
(ii) the exocyclic modification of the intact ring system. Furthermore, although
psoralens have been used in diverse ways, we mainly focus in this work on their clinical
utility for the treatment of psioraisis, vitiligo and skin-related disorder.
