Title:Microwave-assisted One-pot Synthesis of 2-Substituted Quinolines by Using Palladium Nanoparticles as a Catalyst developed from Green Alga Botryococcus braunii
VOLUME: 7 ISSUE: 2
Author(s):Anju Arya, Akhil Mahajan and Tejpal Singh Chundawat*
Affiliation:Department of Applied Sciences, The North Cap University, Sector 23-A, Gurugram-122017, Haryana, Department of Applied Sciences, The North Cap University, Sector 23-A, Gurugram-122017, Haryana, Department of Applied Sciences, The North Cap University, Sector 23-A, Gurugram-122017, Haryana
Keywords:Green alga, microwave heating, palladium nanoparticles, quinolone, Botryococcus braunii, one-pot synthesis.
Abstract:
Background: Quinoline is a type of N-based organic heterocyclic biologically active
compound. Quinolines have grasped the interest of scientists because of their wide scope of applications.
Several methods have been developed for the synthesis of quinoline and its derivatives. In this
study, a new, efficient, simple, one-pot synthesis of the substituted quinolines was developed by using
palladium nanoparticles as a catalyst.
Methods: Catalyst synthesized by algal extract of green alga Botryococcus braunii and palladium acetate
solution, and characterized by different instrumental techniques like FTIR, SEM, and XRD.
The synthesized palladium nanoparticles explored for the catalytic activity in the synthesis of quinoline
derivatives by the use of 2-aminobenzyl alcohol in toluene with acetyl derivatives followed by
the addition of potassium hydroxide. The formation of the product was confirmed by 1HNMR, 13C
NMR, and electron ionization mass spectra.
Results: The formation of palladium nanoparticles characterized by visual observation means the
color change from light pale yellow to dark brown indicates the reduction of palladium ions into palladium
nanoparticles. Synthesized palladium nanoparticles characterized by FTIR spectrum of the
algal extract of green algae B. braunii for the presence of proteins, lipids, carbohydrates, carotenoids,
vitamins and other secondary metabolites in algal extract, which function as active components for
bioreduction. The morphology of the catalyst was confirmed by SEM and X-ray diffraction measurements
for shape, crystalline nature and size. The synthesized palladium nanoparticles explored for
the catalytic activity in the synthesis of quinoline derivatives by use of 2-aminobenzyl alcohol in toluene
and added acetyl derivatives followed by the addition of potassium hydroxide. In order to establish
the optimum heating method, a comparative study between conventional and microwave heating
method was carried out in the presence of palladium nanoparticles as a catalyst.
Conclusion: This protocol provides a convenient and practical procedure for the preparation of quinoline
derivatives from 2-aminobenzyl alcohol, acetyl derivatives, potassium hydroxide and palladium
nanoparticles as a catalyst. This protocol will be helpful in synthesizing other quinoline derivatives
and several organic heterocycles which are used in different fields such as biological, industrial,
pharmaceutical, chemical, medical, etc.
