Aim and Objective: The antibacterial therapy resistance poses an urgent threat to the public’s
health. Peptide deformylase is a favorable target to identify new antibiotics with novel mechanism
Materials and Methods: In order to discovery new potent inhibitors of this enzyme, the virtual
screening method of Zinc database using the binding site of Enterococcus faecalis peptide deformylase
combined with microbiological assay were realized.
Results: The strategy undertaken in this study allowed us to identify new products with growth inhibition
activity. The best result was obtained for the chemicals 4-(1,3-dioxo-1Hbenzo[de]isoquinolin-
2(3H)-yl)-N-hydroxybutanamide and N-hydroxy-2-(3-oxo-3,4-dihydro-2H-1,4-benzothiazin-2-yl)
acetamide, they showed good affinities and great antibacterial activities compared to the other studied
Conclusion: The two most promising compounds can serve as potential antibacterial agents.