Introduction: Finding non-systemic antipyretic option in cancer patients who simultaneously
receive several other drugs seems be logical. This study was designed to evaluate complementary therapy
with Viola odorata L. oil for fever control in febrile neutropenic children.
Methods and Materials: In a randomized placebo controlled clinical trial, 41 febrile children were divided
into two groups. Children in the active drug group received viola oil (20 drops) to be rubbed on the
peripheral margin of the patient umbilicus. Primary outcome measure of the study was the mean axillary
temperature in the 30, 60, and 240 minutes after the intervention.
Results: The mean temperature reduced significantly in the viola group after 30 minutes of administration
(p =0.005), while there was no significant change in the placebo group (p =1.00). The number of patients
who received paracetamol as the rescue treatment was significantly lower in the viola group than
that in the placebo group (5 vs. 17, p =0.001).
Conclusion: The results of our study showed the safety and efficacy of complementary therapy with Viola
odorata L. oil for fever control in febrile neutropenic children during hospital course.