An Efficient and Green Microwave-Assisted Synthesis of Quinoline Derivatives via Knoevengal Condensation

Author(s): Syed Tasqeeruddin*, Yahya Asiri, Jaber Abdullah Alsherhri

Journal Name: Letters in Organic Chemistry

Volume 17 , Issue 2 , 2020

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Abstract:

We have developed an efficient and green synthesis of quinoline derivatives using L-proline under Knoevenagel condensation. L-proline was found to be an efficient catalyst for the Knoevenagel condensation of substituted 2-aminoaryl ketones 1 with the active methylene compounds 2, affording quinolone derivatives 3. The reaction has been done under conventional as well as under microwave conditions. The latter procedure has been found to be much more efficient in terms of time and yield.

Keywords: L-proline, Knoevenagel condensation, substituted 2-arylketones, active methylene compounds, microwave irradiation, quinoline derivatives.

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VOLUME: 17
ISSUE: 2
Year: 2020
Page: [157 - 163]
Pages: 7
DOI: 10.2174/1570178616666190618153721
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