Background & Aims: It is well-known that the coronary artery stenosis is related to lipid
profile. This is a descriptive cross-sectional study to investigate the relationship between the serum
fat-soluble vitamins (A, E and D), circulating proprotein convertase subtilisin/kexin type 9
(PCSK9), and lipid profile in the study population.
Methods: A total of 120 overweight subjects were participated in this study. The circulating
PCSK9 and vitamin D were measured by ELISA technique. The serum vitamin A and vitamin E
amounts were simultaneously measured by the HPLC method. The Serum Small Dense LDLCholesterol
(sdLDL-C) values were evaluated using heparin-Mg2+ precipitation technique. The lipid
profile was measured by routine laboratory techniques.
Results: The serum vitamin E values correlated significantly to vitamin A (r= 0.47, P= 0.0001),
VLDL-C (r= 0.30, P= 0.002), total cholesterol (r= 0.309, P= 0.001), PCSK9 (r= 0.233, P= 0.01)
and total triglyceride (r= 0.61, P= 0.0001) values. The circulating PCSK9 values correlated significantly
to LDL-C (r= 0.17, P= 0.05) and total cholesterol (r= 0.23, P= 0.009) values. However, there
were not correlations between the levels of serum D and A vitamins, the serum LDL-C, sdLDL-C
and total cholesterol values.
Conclusion: The data showed the correlations between serum vitamin E and PCSK9-related LDLC
values lower than the normal range. Furthermore, the results suggested a nutritional need on the
patents considering supplementation or fortification of vitamin E for the overweight subjects with
higher LDL-C levels.