Viral myocarditis is a cardiac disease caused by Group B Coxsackie virus of Enterovirus
genus in the Picorna viridae family. It causes heart failure in children, young and adults. Ten Percent
(10%) of acute heart failure and 12% of sudden deaths in young and adults who are less than 40 years
is due to this viral myocarditis. If treatment action is not taken earlier, the viral disease can develop
into chronic myocarditis and Dilated Cardiomyopathy which lead to congestive heart failure. And
these eventually result in a reduced cardiac function which finally brings the victim to death. The only
treatment option of the disease is heart transplantation once the acute stage of disease develops to
chronic and Dilated Cardiomyopathy. Currently, there is a limitation in daily clinical treatments and
even some available treatment options are ineffective. Therefore, focusing on search for treatment options
through investigation is imperative. Recent studies have reported that biological molecules show
a promising role. But their mechanism of pathogenesis is still unclear. A detailed study on identifying
the role of biological molecules involved in Coxsackie B3 virus induced myocarditis and their mechanisms
of pathogenesis; compiling and disseminating the findings of the investigation to the scientific
communities contribute one step forward to the solution. Therefore, this review is aimed at compiling
information from findings of current studies on the potential therapeutic role of micro RNA, cytokines
and chemokines on the mechanism of pathogenesis of Coxsackie virus B3- induced myocarditis to
give brief information for scholars to conduct a detailed study in the area.
Keywords: CVB3, Viral myocarditis, Dilated Cardiomyopathy, micro RNA, Cytokines, Chemokines.
Blauwet LA, Cooper LT. Myocarditis. Prog cardiovac Dis 2010; 52: 274-88..
van Regenmortel, Marc HF, Claude MB, et al. Virus taxonomy: classification and nomenclature of viruses.Seventh report of the International Committee on Taxonomy of Viruses. ICTV 7 Report Academic Press. 2000..
Gulati K, Guhathakurta S, Joshi J, Rai N, Ray A. Cytokines and their role in health and disease: A brief overview. MOJ Immunol 2016; 4: 00121.
Rights & PermissionsPrintExport