Medicinal plants have curative properties due to the presence of various complex chemical
substances of different composition, which are found as secondary metabolites in one or more
parts of the plant. The diverse secondary metabolites play an important role in the prevention and
cure of various diseases including neurodegenerative diseases like Alzheimer’s disease. Naturally
occurring compounds such as flavonoids, polyphenols, alkaloids, and glycosides found in various
parts of the plant and/or marine sources may potentially protect neurodegeneration as well as improve
memory and cognitive function. Many natural compounds show anti-Alzheimer activity
through specific pharmacological mechanisms like targeting β-amyloid, Beta-secretase 1 and Acetylcholinesterase.
In this review, we have compiled more than 130 natural products with a broad
diversity in the class of compounds, which were isolated from different sources showing anti-
Keywords: Alzheimer’s disease, natural product, alternative treatment, plants.
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