Background: An increase in poorly water-soluble drugs makes the design of drug delivery systems
Methods: Currently, a number of prospective solid dispersions have been investigated with potential applications
for delivering a variety of poorly water-soluble drugs. A number of traditional solid dispersions and modifiedsolid
dispersions offer attractive advantages in the fabrication, design and development of those drugs for effective
Results: Although traditional solid dispersions can produce a higher release rate, resulting in higher bioavailability
compared to conventional dosage forms, this method is not always a promising approach. Modified-solid
dispersion has demonstrated both the ability of its polymers to transform drug crystals into amorphous forms and
molecular interactivity, thereby improving drug dissolution rate and bioavailability, especially with tough drugs.
However, the classification of modified-solid dispersion, which guides the selection of the right strategy in solid
dispersion preparation, remains ill-defined.
Conclusion: This review focused on effective strategies in using additives in solid dispersion for improving drug