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Current Protein & Peptide Science

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ISSN (Print): 1389-2037
ISSN (Online): 1875-5550

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Review Article

Roles of E6 and E7 Human Papillomavirus Proteins in Molecular Pathogenesis of Cervical Cancer

Author(s): Eskandar Taghizadeh, Sepideh Jahangiri, Daryoush Rostami, Forough Taheri, Pedram Ghorbani Renani, Hassan Taghizadeh and Seyed Mohammad Gheibi Hayat*

Volume 20, Issue 9, 2019

Page: [926 - 934] Pages: 9

DOI: 10.2174/1389203720666190618101441

Price: $65

Abstract

Human papillomavirus (HPV) cancers are expected to be major global health concerns in the upcoming decades. The growth of HPV-positive cancer cells depends on the consistent expression of oncoprotein which has been poorly taken into account in the cellular communication. Among them, E6/E7 oncoproteins are attractive therapeutic targets as their inhibition rapidly leads to the onset of aging in HPV-positive cancer cells. This cellular response is associated with the regeneration of p53, pRb anti-proliferative proteins as well as the mTOR signaling pathway; hence, the identification of involved and application of E6/E7 inhibitors can lead to new therapeutic strategies. In the present review, we focused on the pathogenicity of E6/E7 Proteins of human papillomavirus and their roles associated with the cervical cancer.

Keywords: Human papillomavirus, cervical cancer, E6/E7 proteins, oncoprotein, cancer cells, pathogenicity.

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