Roles of E6 and E7 Human Papillomavirus Proteins in Molecular Pathogenesis of Cervical Cancer

Author(s): Eskandar Taghizadeh, Sepideh Jahangiri, Daryoush Rostami, Forough Taheri, Pedram Ghorbani Renani, Hassan Taghizadeh, Seyed Mohammad Gheibi Hayat*

Journal Name: Current Protein & Peptide Science

Volume 20 , Issue 9 , 2019

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Graphical Abstract:


Human papillomavirus (HPV) cancers are expected to be major global health concerns in the upcoming decades. The growth of HPV-positive cancer cells depends on the consistent expression of oncoprotein which has been poorly taken into account in the cellular communication. Among them, E6/E7 oncoproteins are attractive therapeutic targets as their inhibition rapidly leads to the onset of aging in HPV-positive cancer cells. This cellular response is associated with the regeneration of p53, pRb anti-proliferative proteins as well as the mTOR signaling pathway; hence, the identification of involved and application of E6/E7 inhibitors can lead to new therapeutic strategies. In the present review, we focused on the pathogenicity of E6/E7 Proteins of human papillomavirus and their roles associated with the cervical cancer.

Keywords: Human papillomavirus, cervical cancer, E6/E7 proteins, oncoprotein, cancer cells, pathogenicity.

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Article Details

Year: 2019
Published on: 16 September, 2019
Page: [926 - 934]
Pages: 9
DOI: 10.2174/1389203720666190618101441
Price: $65

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