Traumatic Brain Injury (TBI) is one of the main causes of mortality and morbidity
worldwide with no suitable treatment. The present study was designed to review the present literature
about the protective effects of curcumin and the underlying mechanism against TBI. All published
English language papers from beginning to 2019 were selected in this study. The findings
indicate that curcumin may be effective against TBI outcomes by modulating the molecular signaling
pathways involved in oxidative stress, inflammation, apoptosis, and autophagy. However, more
experimental studies should be done to identify all mechanisms involved in the pathogenesis of
TBI. Patents for Curcumin and chronic inflammation and traumatic brain injury management
(WO2017097805A1 and US9101580B2) were published. In conclusion, the present study confirmed
the potential therapeutic impact of curcumin for treating TBI.
Keywords: Curcumin, traumatic brain injury, inflammation, oxidative stress, apoptosis, autophagy.
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