Phytochemical and Pharmacological Review on Two Herbs of Baijiangcao: Patrinia scabiosaefolia Fisch. ex Trev. and Patrinia villosa (Thunb.) Juss

Author(s): Yangcheng Liu, Wei Liu, Jiaqi Wang, Yang Liu, Changlan Chen*, Zheng Xiang*

Journal Name: Mini-Reviews in Organic Chemistry

Volume 17 , Issue 5 , 2020


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Abstract:

Patrinia scabiosaefolia Fisch. Trev. and Patrinia villosa (Thunb.) Juss, are two species of Patrinia recorded in the Chinese Pharmacopoeia with the same Chinese name “Baijiangcao” and similar therapeutic effect in traditional Chinese medicine. The present article is the first comprehensive review on the chemical composition and pharmacological activities of these herbs. In this review, data on chemical constituents and pharmacological profile of the two herbs are provided. This review discusses all the classes of the 223 compounds (phenylpropanoids, flavonoids, terpenes, saponins and volatile components, etc.) detected in the two herbs providing information on the current state of knowledge of the phytochemicals present in them. In the past three years, our research group has isolated and identified about more than 100 ingredients from the two herbs. Therefore, we published a systematic review of our research papers and studies on the two herbs were carried out using resources such as classic books about Chinese herbal medicine and scientific databases including Pubmed, Web of Science, SciFinder, CNKI. etc. The present review discusses the most thoroughly studied pharmacological activities (antioxidant, anti-inflammatory, immunomodulatory, antimicrobial, antitumor and antiviral activities) of the two herbs. This comprehensive review will be informative for scientists searching for new properties of these herbs and will be important and significant for the discovery of bioactive compounds from the two herbs and in complete utilization of Patrinia scabiosaefolia Fisch. ex Trev. and Patrinia villosa (Thunb.) Juss.

Keywords: Patrinia scabiosaefolia Fisch. ex Trev., Patrinia villosa (Thunb.) Juss, pharmacological, basal leaves, perennial herbs, phytochemical.

[1]
Editorial Committee of Flora of China. Chinese Academy of Sciences. In: Flora of China; The Science Publishing Company: Beijing, 2013.
[2]
Wang, T.Z.; Lou, Z.C. Morphological and histological studies of the Chinese drug Bai-Jiang-Cao: I. Drugs derived from Valerianaceae. Yao Xue Xue Bao, 1985, 20(2), 123-136.
[PMID: 4036617]
[3]
Wang, L.J.; Li, Y.J. Research Of Patrinia Plants From Shennong Bencao Jing. Chin. Tradit. Herbal Drugs, 2004, 35(6), 696-697.
[4]
Miao, S.P. Distinction between Patrinia villosa, Patrinia scabiosaefolia and its adulterants. Strait. Pharm. J., 2002, 14(6), 60-62.
[5]
Yang, X.H. Variety identification and application of Patrinia plants. Shanxi J. TCM., 2005, 21(6), 44.
[6]
Chinese Pharmacopoeia Commission. The Chinese Pharmacopoeia; Interpharm Press Inc., 2015.
[7]
Wang, Q. Research progress of Patrinia villosa and Patrinia scabiosaefolia. Med. Rec., 2009, 15(13), 2021-2022.
[8]
Kong, L.B.; Zhao, J. Progress in clinical application of Patrinia villosa and Patrinia scabiosaefolia. Chin. J. Mod. Drug. Appl., 2008, 2(8), 113-114.
[9]
Yan, X.J.; Zheng, W.; Wen, J.; Wu, J.; Xu, Y.; Cao, L.; Wang, H.X.; Xiang, Z. Chemical constituents of Patrinia villosa. Chin. Tradit. Herbal Drugs, 2017, 48(2), 247-251.
[10]
Zhao, Z.Y.; Yang, J. Analysis of chemical constituents of Patrinia scabiosaefolia Fisch. J. Liaoning. Med. Univ., 2016, 37(2), 16-18.
[11]
Xiang, Z.; Chen, N.; Xu, Y.; Wu, J.; Liu, Y.J.; Tan, C.; Ji, Y.B.; Li, W.L. New flavonoid from Patrinia villosa. Pharm. Biol., 2016, 54(7), 1219-1222.
[PMID: 26155822]
[12]
Choi, J.S.; Woo, W.S. Coumarins and triterpenoid glycosides from the roots of Patrinia scabiosaefolia. Arch. Pharm. Res., 1984, 7(2), 121-126.
[http://dx.doi.org/10.1007/BF02856624]
[13]
Xia, M.W.; Tan, J.J.; Yang, L.; Shang, Z.P.; Zhao, Q.C.; Shi, G.B. Studies on chemcial constituents in Patrinia scabiosaefolia. Chin. Tradit. Herbal Drugs, 2010, 41(10), 1612-1615.
[14]
Yan, X.J.; Zheng, W.; Wen, J.; Wu, J.; Bai, M.; Xiang, Z. Lignan constituents of Patrinia villosa (Thunb.). Juss. Chin. Pharm. J., 2017, 52(13), 1126-1131.
[15]
Bao, Y.R.; Yan, X.J.; Yang, X.X.; Wang, S.; Zhao, L.; Bai, M.; Xiang, Z. Study on chemical constituents of Patrinia villosa. Chin. Med. Mat., 2017, 40(2), 347-349.
[16]
Xiang, Z.; Zhao, S.S.; Zhao, Y.; Li, N.; Wu, J.; Chen, C.L.; Liu, H.W. Chemical constituents from Patrinia villosa (Thunb.). Juss. Lat. Am. J. Pharm., 2017, 36(12), 2425-2430.
[17]
Xin-Jia, Y.; Wei, L.; Ying, Z.; Ning, C.; Ying, X.; Jian, W.; Tan, W.; Yue, L.; Zheng, X. A New biphenyl neolignan from leaves of Patrinia villosa (Thunb.). Pharmacogn. Mag., 2016, 12(45), 1-3.
[http://dx.doi.org/10.4103/0973-1296.175988] [PMID: 27019553]
[18]
Liu, H.T.; Zhu, L.; Lei, P.; Lan, S.N.; Huang, H.F. Simultaneous determination of quercetin and kaempferol in Herba Patriniae by RP-HPLC. Cent. South. Pharm., 2015, 13(3), 291-294.
[19]
Peng, J.Y.; Fan, G.R.; Wu, Y.T. Isolation and structure identification of chemical constituents from Patrinia villosa. Yao Xue Xue Bao, 2006, 41(3), 236-240.
[PMID: 16758995]
[20]
Peng, J.Y.; Fan, G.R.; Wu, Y.T. Isolation and separation of flavones from Patrinia villosa by high-speed counter-current chromatography. Chung Kuo Yao Hsueh Tsa Chih, 2006, 41(13), 977-979.
[21]
Huang, L.; Zhang, R.S.; Wang, C.F.; Zhang, S.F. Studies on chemical constituents of Patrinia villosa. Zhong Yao Cai, 2007, 30(4), 415-417.
[PMID: 17674792]
[22]
Peng, J.; Fan, G.; Hong, Z.; Chai, Y.; Wu, Y. Preparative separation of isovitexin and isoorientin from Patrinia villosa Juss by high-speed counter-current chromatography. J. Chromatogr. A, 2005, 1074(1-2), 111-115.
[http://dx.doi.org/10.1016/j.chroma.2005.03.067] [PMID: 15941046]
[23]
Peng, J.; Fan, G.; Wu, Y. Preparative isolation of four new and two known flavonoids from the leaf of Patrinia villosa Juss. by counter-current chromatography and evaluation of their anticancer activities in vitro. J. Chromatogr. A, 2006, 1115(1-2), 103-111.
[http://dx.doi.org/10.1016/j.chroma.2006.02.079] [PMID: 16545824]
[24]
Peng, J.Y.; Fan, G.R.; Wu, Y.T.; Chen, H.Y. Isolation and purification of prenylated flavonoids from Patrinia villosa Juss by reversed phase preparative liquid chromatography. Chin. J. Anal. Chem., 2006, 34(7), 983-986.
[25]
Lee, J.Y.; Kim, J.S.; Kim, Y.S.; Kang, S.S. Glycosides from the aerial parts of Patrinia villosa. Chem. Pharm. Bull. (Tokyo), 2013, 61(9), 971-978.
[http://dx.doi.org/10.1248/cpb.c13-00306] [PMID: 23800854]
[26]
Di, L.; Li, N.; Zu, L.B.; Wang, K.J.; Zhao, Y.X.; Wang, Z. ChemInform abstract: Three new iridoid glucosides from the roots of Patrinia scabra. B. Kor. Chem. Soc., 2011, 32(9), 3251-3254.
[http://dx.doi.org/10.5012/bkcs.2011.32.9.3251]
[27]
Huang, X.D.; Huang, X.K.; Li, H.Z.; Jiang, L.J.; Zhang, H.Y. Chemical components and DPPH• radical scavenging activities of the volatiles from Patrinia villosa leaves. Food. Sci. Technol., 2012, 37(10), 187-191.
[28]
Takeda, S.; Yuasa, K.; Endo, T.; Aburada, M. Pharmacological studies on iridoid compounds. II. Relationship between structures and choleretic actions of iridoid compound. J. Pharmacobiodyn., 1980, 3(10), 485-492.
[http://dx.doi.org/10.1248/bpb1978.3.485] [PMID: 7205532]
[29]
Choi, E.J.; Liu, Q.H.; Jin, Q.; Shin, J.E.; Hong, J.; Lee, D.G.; Woo, E.R. New iridoid esters from the roots of Patrinia scabiosaefolia. B. Kor. Chem. Soc., 2009, 40(45), 1407-1409.
[30]
Gao, L.; Zhang, L.; Wang, L.M.; Liu, J.Y.; Cai, P.L.; Yang, S.L. New triterpenoid saponins from Patrinia scabiosifolia. J. Asian Nat. Prod. Res., 2012, 14(4), 333-341.
[http://dx.doi.org/10.1080/10286020.2011.653685] [PMID: 22375871]
[31]
Yang, M.Y.; Choi, Y.H.; Yeo, H.; Kim, J. A new triterpene lactone from the roots of Patrinia scabiosaefolia. Arch. Pharm. Res., 2001, 24(5), 416-417.
[http://dx.doi.org/10.1007/BF02975186] [PMID: 11693542]
[32]
Gao, L.; Zhang, L.; Liu, J.Y.; Cai, P.L.; Yang, S.L. Chemical constituents of Patrinia scabiosaefolia. Chin. Tradit. Herbal Drugs, 2011, 42(8), 1477-1480.
[33]
Yang, B.; Fu, Z.Z.; Zhang, Y.; Chen, Y.J. Isolation and identification of a new saponin from Dahurian patrinia root and rhizome (Patrinia scabiosaefolia). Chin. Tradit. Herbal Drugs, 2000, 31(1), 1-2.
[34]
Nakanishi, T.; Tanaka, K.; Murata, H.; Somekawa, M.; Inada, A. Phytochemical studies of seeds of medicinal plants. III. Ursolic acid and oleanolic acid glycosides from seeds of Patrinia scabiosaefolia Fischer. Chem. Pharm. Bull. (Tokyo), 1993, 41(1), 183-186.
[http://dx.doi.org/10.1248/cpb.41.183] [PMID: 8448818]
[35]
Bukharov, V.G.; Karlin, V.V. Triterpene glycosides of Patrinia scabiosofolia; II. Chem. Nat. Compd., 1973, 6(2), 206-208.
[http://dx.doi.org/10.1007/BF00941682]
[36]
Gao, L.; Zhang, L.; Li, N.; Liu, J.Y.; Cai, P.L.; Yang, S.L. New triterpenoid saponins from Patrinia scabiosaefolia. Carbohydr. Res., 2011, 346(18), 2881-2885.
[http://dx.doi.org/10.1016/j.carres.2011.10.008] [PMID: 22050996]
[37]
Bukharov, V.G.; Karlin, V.V.; Sidorovich, T.N. Triterpene glycosides of Patrinia scabiosofolia. I. Chem. Nat. Compd., 1970, 6(2), 206-208.
[http://dx.doi.org/10.1007/BF00941682]
[38]
Li, Y.F.; Lou, F.C. Isolation and identification of triterpenoid sapon ins from Patrinia scabiosaefolia Fisch. Huaxi Yaoxue Zazhi, 2007, 22(5), 483-486.
[39]
Kim, Y.M. Studies on components of Patrinia scabiosaefolia. Korean. J. Pharm. (Cairo), 1997, 93-98.
[40]
Yang, D.H.; Wei, L.X.; Cai, S.Q.; Wang, X. [Studies on the chemical constituents of Patrinia scabiasaefolia fisch]. Zhongguo Zhongyao Zazhi, 2000, 25(1), 39-41.
[PMID: 12205973]
[41]
Yang, L.; Jiang, H.; Wang, X.Y.; Liu, C. Advances in chemical constituents and pharmacological activities of Patrinia villosa. Info. Tradit. Chin. Med., 2012, 29(4), 169-172.
[42]
Choi, J.S.; Woo, W.S. Triterpenoid glycosides from the roots of Patrinia scabiosaefolia. Planta Med., 1987, 53(1), 62-65.
[http://dx.doi.org/10.1055/s-2006-962622] [PMID: 17268965]
[43]
Kang, S.S.; Kim, J.S.; Kim, Y.H.; Choi, J.S. A triterpenoid saponin from Patrinia scabiosaefolia. J. Nat. Prod., 1997, 60(10), 1060-1062.
[http://dx.doi.org/10.1021/np970175v] [PMID: 9358650]
[44]
Inada, A.; Yamada, M.; Murata, H.; Kobayashi, M.; Toya, H.; Kato, Y.; Nakanishi, T. Phytochemical studies of seeds of medicinal plants. I. Two sulfated triterpenoid glycosides, sulfapatrinosides I and II, from seeds of Patrinia scabiosaefolia FISCHER. Chem. Pharm. Bull. (Tokyo), 1988, 36(11), 4269-4274.
[http://dx.doi.org/10.1248/cpb.36.4269] [PMID: 3246001]
[45]
Xiang, Z.; Yan, X.J.; Wen, J.; Liu, W. Chemical constituents of whole plants of Patrinia villosa (Thunb.). Juss. Chin. Pharm. J., 2017, 52(3), 185-187.
[46]
Wu, J.; Xu, Y.; Xiang, Z. Chemical compositong of essential oil from the leaves of two species of baijingcao, Patrinia scabiosaefolia Fisch and Patrinia villosa (Thunb. Juss). International Conference on Energy & Environmental Protection, November 21-23,; , 2016. in Sanya, China.
[47]
Liu, F.Y. Clinical application of Patrinia villosa. J. Tradit. Chin. Med., 2002, 43(12), 893.
[48]
Li, S.H.; Wang, J.R.; Cheng, G.; Wang, X.P. Comparative study of anti-inflammatory effects of four Chinese herbals in mice. Hubei. Agric. Sci., 2013, 52(4), 892-894.
[49]
Lim, J.P.; Xun, C. Anti-inflammatory effect of Patrinia villosa extract on proteinase-activated receptor-2 mediated paw edema. Hanguk Yakyong Changmul Hakhoe Chi, 2004, 12(1), 47-52.
[50]
Zheng, Y.; Jin, Y.; Zhu, H.B.; Xu, S.T.; Xia, Y.X.; Huang, Y. The anti-inflammatory and anti-nociceptive activities of Patrinia villosa and its mechanism on the proinflammatory cytokines of rats with pelvic inflammation. Afr. J. Tradit. Complement. Altern. Med., 2012, 9(3), 295-302.
[http://dx.doi.org/10.4314/ajtcam.v9i3.1] [PMID: 23983359]
[51]
Weng, F.H.; Hu, P.; Jiao, J.J. Effect of anti-inflammatory action of Chinese herbs on the synthesis of LTB4 and 5-HETE of peritoneal macrophages in rats. J. Tianjin. Med. Univ., 1996, 2(1), 1-3.
[52]
Seo, S.W.; Park, C.S.; Hong, S.H.; Kwon, K.B.; Moon, H.C.; Song, B.K.; Kim, K.Y.; Park, Y.M.; Song, H.J.; Kim, H.M.; Park, S.J. Inhibitory effect of Patrinia scabiosaefolia on acute pancreatitis. World J. Gastroenterol., 2006, 12(7), 1110-1114.
[http://dx.doi.org/10.3748/wjg.v12.i7.1110] [PMID: 16534854]
[53]
Cho, E.J.; Shin, J.S.; Noh, Y.S.; Cho, Y.W.; Hong, S.J.; Park, J.H.; Lee, J.Y.; Lee, J.Y.; Lee, K.T. Anti-inflammatory effects of methanol extract of Patrinia scabiosaefolia in mice with ulcerative colitis. J. Ethnopharmacol., 2011, 136(3), 428-435.
[http://dx.doi.org/10.1016/j.jep.2010.04.047] [PMID: 20573566]
[54]
Ye, Z.X.; Su, J.F.; Huang, X.D. Pharmacodynamic study of methanol extract of Patrinia scabiosaefolia on ulcerative colitis in mice. J. New Chin. Med., 2013, 45(9), 157-159.
[55]
Han, L.; Liu, C.H. Impact of herba Patriniae on TNF-α, IL-1β and IL-10 expression in colonic tissue of rats with experimental ulcerative colitis. Jinri. Yaoxue., 2013, 23(2), 78-80.
[56]
Zhang, T.; Li, Q.; Li, K.; Li, Y.; Li, J.; Wang, G.; Zhou, S. Antitumor effects of saponin extract from Patrinia villosa (Thunb.) Juss on mice bearing U14 cervical cancer. Phytother. Res., 2008, 22(5), 640-645.
[http://dx.doi.org/10.1002/ptr.2354] [PMID: 18350512]
[57]
Chen, L.; Zhang, T.; Tian, L.M.; Chen, P.; Wang, D.W.; Lu, C.F.; Yan, D.M. Inhibitory effect of Patrinia villosa extract on U14 cervical cancer cells in mice. Zhongguo Laonianxue Zazhi, 2004, 8, 1091-1093.
[58]
Zhang, T.; Tian, L.M.; Wang, Z.; Tian, L.H. Effect of Patrinia villosa on tumor cell cycle and PCNA expression in U14 tumor-bearing mice. Heilongjiang Yiyao Kexue, 2011, 34(3), 84-85.
[59]
Yang, X.L.; Li, Q.W.; Li, J. Study on the anti-cervical cancer activity of Patrinia villosa flavonoids. Heilongjiang. Anim. Sci. Vet. Med., 2009, 10, 106-107.
[60]
Piao, C.Y.; Fang, C.; Zhang, Y.; Chen, T.T.; Zhou, Z.G. Study on the inhibitory effect of Patrinia villosa active composition on Siha cells in vitro. Heilongjiang. Sci., 2015, 6(2), 10-11.
[61]
Song, T.; Sun, H.; Lu, J.; Li, F.J.; Zhang, Z.Y.; Chen, X. The Anti-tumor effect of the extracts of Patrinia villosa Juss. Lishizhen Med. Mater. Med. Res., 2012, 23(10), 2410-2412.
[62]
Zhang, T.; Tian, L.M.; Zhu, M.G.; Ren, J.Q.; Zhang, Y.; Tian, L.H. Caspase-3 involved in apoptosis of Hela cells induced by Patrinia Villosa saponins. Zhongguo Laonianxue Zazhi, 2012, 6(32), 2321-2323.
[63]
Lei, J.C.; Yang, C.X.; Yang, Y.; Zhang, W.; Yu, J.Q. Antioxidant and antitumour activities of extracts from Patrinia villosa and its active constituents. J. Funct. Foods, 2015, 16, 289-294.
[http://dx.doi.org/10.1016/j.jff.2015.04.037]
[64]
Lv, P.T.; Sun, Y.G.; Liu, B. Immunomodulatory effect of Patrinia polysaccharide and its effect on S180 tumor-bearing mice. Zhong Yao Cai, 2017, 40(1), 212-215.
[65]
Ding, Y.X.; Li, Y.; Chen, Y.Z.; Chen, J.; Zhang, R.S. Studies on Anti-tumor activity in vitro of laricircsinol from Patrinia villosa Juss. Chin. Arch. Ttadit. Chin. Med., 2012, 30(2), 420-422.
[66]
Li, Y.J.; Zhang, S.N.; Li, J.; Wang, C.T. Effect of Patrinia scabiosaefolia on blood metastasis of hepatoma cells. Food. Drug., 2013, 15(4), 248-250.
[67]
Mao, J.J.; Wang, L.M.; Zhang, Y.M.; Liu, L.; Lu, Y.Z.; Fu, C.F.; Fu, Z.Z.; Yang, B.; Zhang, Y.; Tong, L.H. Experimental observation on antitumor effect of Patrinia scabiosaefolia Fisch extract. Heilongjiang Yiyao Kexue, 2004, 247(5), 35.
[68]
Shen, D.F.; Yang, B.; Li, J.J. Experimental research on the function of anti-cancer in the saponins from Patrinia scabiosaefolia Fisch. Heilongjiang Yiyao Kexue, 2007, 30(3), 35.
[69]
Peng, J.; Chen, Y.; Lin, J.; Zhuang, Q.; Xu, W.; Hong, Z.; Sferra, T.J. Patrinia scabiosaefolia extract suppresses proliferation and promotes apoptosis by inhibiting the STAT3 pathway in human multiple myeloma cells. Mol. Med. Rep., 2011, 4(2), 313-318.
[PMID: 21468570]
[70]
Liu, L.; Shen, A.; Chen, Y.; Wei, L.; Lin, J.; Sferra, T.J.; Hong, Z.; Peng, J. Patrinia scabiosaefolia induces mitochondrial-dependent apoptosis in a mouse model of colorectal cancer. Oncol. Rep., 2013, 30(2), 897-903.
[http://dx.doi.org/10.3892/or.2013.2528] [PMID: 23754194]
[71]
Zhang, M.; Sun, G.; Shen, A.; Liu, L.; Ding, J.; Peng, J. Patrinia scabiosaefolia inhibits the proliferation of colorectal cancer in vitro and in vivo via G1/S cell cycle arrest. Oncol. Rep., 2015, 33(2), 856-860.
[http://dx.doi.org/10.3892/or.2014.3663] [PMID: 25500894]
[72]
Dai, C.J.; Lin, P.Q. Study on antimicrobialactions and stability of Patrinia villosa charantia extractive. Food Machinery, 2011, 27(6), 157-159.
[73]
Dong, Y.; Qi, W. Antibacterial activity of the chemical compositions from Patrinia scabiosaefolia Fisch. Chung Kuo Yao Hsueh Tsa Chih, 2014, 49(9), 717-720.
[74]
Zhang, F.M.; Li, H.Y.; Li, X.; Liu, X.Y.; Wang, X.Q.; Chen, Z.H.; Xie, Z.P.; Li, X. In vitro anti-respiratory syncytial virus effect of an active compound (AP4) from Herba patriniae. Heilongjiang Yiyao Kexue, 2006, 29(1), 48-50.
[75]
Li, S.S.; Li, H.Y.; Piao, Y.A.; Liu, D.L.; Tian, W.J.; Dong, Y.M. The anti-respiratory syncytial virus effect of an active compound (AP3) from a Chinese medicinal herb Herba patriniae in vitro. Zhonghua Liu Xing Bing Xue Za Zhi, 2004, 25(2), 150-153.
[PMID: 15132871]
[76]
Chen, Y.P.; Zeng, J.; Ye, H.Y. Inhibitory effect of qaueous extract of Patrina villosa Juss on central nerve system. Chin. Remed. Clin., 2005, 5(6), 439-440.
[77]
Xiao, Z.; Peng, X.D. Studies on the sedation active site of Patrinia scabiosaefolia Fisch. Guangzhou. Med. J., 2010, 41(6), 53-55.
[78]
Peng, X.D.; Wang, X.F. Comparison of sedative efects of diferent fractions from Patrinia scabiosaefolia Fisch in mice. J. Chin. Physicia., 2010, 12(8), 1022-1024.
[79]
Xu, Z.M.; Huang, C.H.; Zhu, B.; Zhang, Y.H. Study on the sedative active components of Patrinia scabiosaefolia. Zhejiang. J. Integr. Tradit. Chin. West. Med., 2007, 17(6), 347-348.
[80]
Zhu, J.J.; Wu, X.Y.; Zou, S.J.; Wu, J. Extraction technology and anti-constipation function of tannins from wild Patrinia villosa. T. CSAE, 2003, 19(2), 186-189.
[81]
Guo, X.Q.; Xu, J.; Zeng, L.; Zhang, W.R.; Zeng, J. Experimental study of Patrina villosa Juss. extractive on benign prostatic hyperplasia model of mice. Chin. Mode. Med., 2013, 20(33), 33-34.
[82]
He, G.H.; Zeng, J.; Tan, X.B.; Jiang, L.X. Anti-oxidation effect of ethanol extract of Patrina villosa Juss. in mice. Chin. Mode. Med., 2015, 22(18), 4-5.
[83]
Jeon, J.; Lee, J.; Kim, C.; An, Y.; Choi, C. Aqueous extract of the medicinal plant Patrinia villosa Juss. induces angiogenesis via activation of focal adhesion kinase. Microvasc. Res., 2010, 80(3), 303-309.
[http://dx.doi.org/10.1016/j.mvr.2010.05.009] [PMID: 20594998]
[84]
Chen, X.; Yan, X.; Guo, L. Inhibitory effect of Patrinia on BRL-3A cell apoptosis through the TLR4/PI3K/AKT/GSK3β and TLR4/P38/JNK signaling pathways. Mol. Med. Rep., 2018, 17(4), 5344-5349.
[http://dx.doi.org/10.3892/mmr.2018.8466] [PMID: 29363726]
[85]
Li, P.F. Influence of Herba patrinia on endotoxin-stimulated secretory cell factor macrophage and its mechanism. New Tradit. Chin. Med., 2001, 33(2), 75-76.
[86]
Lodhi, S.; Vadnere, G.P.; Sharma, V.K.; Usman, M.R. Marrubium vulgare L.: A review on phytochemical and pharmacological aspects. J. Intercult. Ethnopharmacol., 2017, 6(4), 429-452.
[http://dx.doi.org/10.5455/jice.20170713060840]


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VOLUME: 17
ISSUE: 5
Year: 2020
Published on: 11 August, 2020
Page: [496 - 517]
Pages: 22
DOI: 10.2174/1570193X16666190617161124
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