Naringenin Scaffold as a Template for Drug Designing

Author(s): Yogesh Murti*, Bhupesh Chander Semwal, Ahsas Goyal, Pradeep Mishra

Journal Name: Current Traditional Medicine

Volume 7 , Issue 1 , 2021

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Graphical Abstract:


Natural products provide cornucopia of heterocyclic systems. The nucleus of 2- phenyl chromane is one of the important and well-known heterocycles found in the natural products. Naringenin, a plant-derived flavanone (2-phenyl chroman-4-one) belongs to the family of flavanoids. It possesses diverse biologic activities such as antidiabetic, antiatherogenic, antidepressant, antiandrogenic, antiestrogenic, immunomodulatory, antitumor, antimicrobial, anti-inflammatory, antiviral, hypolipidemic, antihypertensive, antioxidant, neuroprotective, anti-obesity, anti-Alzheimer, and memory enhancer activity. It has the potential to be used as an active pharmacophore. There have been reports of a number of molecular mechanisms underlying their beneficial activities. With emerging interest in traditional medicine and exploiting their potential based on a variety of health care systems, naringenin literature was thought to be explored. Further, this review aims to provide a new era of flavonoid-based therapeutic agents with new insights into naringenin and its derivatives as a lead compound in drug design.

Keywords: Naringenin, flavanone, pharmacophore, drug design, flavanoids, lead compound.

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Article Details

Year: 2021
Published on: 04 February, 2021
Page: [28 - 44]
Pages: 17
DOI: 10.2174/2215083805666190617144652
Price: $25

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