Alpha-1 Antitrypsin Deficiency and Chronic Obstructive Pulmonary Disease: Between Overlaps, Phenotypes and Illnesses

Author(s): Alexandru Corlateanu*, Serghei Covantev, Irina Caraivanova, Vlada Bodrug, Victor Botnaru, Joseph Varon, Nikolaos Siafakas

Journal Name: Current Respiratory Medicine Reviews

Volume 15 , Issue 2 , 2019

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Graphical Abstract:


Alpha-1 antitrypsin deficiency (AATD) or alpha-1 antitrypsin proteinase inhibitor (α1-Pi) deficiency, is a genetic disorder leading to a higher risk of pulmonary, hepatic and other organrelated diseases. The spectrum of diseases associated with AATD is large and includes pulmonary conditions (COPD, asthma, asthma-COPD overlap syndrome, bronchiectasis, etc.) as well as extrapulmonary (liver diseases, systemic vasculitis, rheumatoid arthritis, panniculitis, multiple sclerosis, peripheral neuropathy). We present a review of AATD focusing on its connection to other conditions.

Keywords: Alpha-1 antitrypsin deficiency, COPD, phenotypes, illness, syndrome, bronchiectasis.

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Article Details

Year: 2019
Published on: 10 December, 2019
Page: [147 - 155]
Pages: 9
DOI: 10.2174/1573398X15666190617143122

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