Serum Vitamin D Levels in Children with Immune Thrombocytopenia

Author(s): Giuseppe Lassandro, Francesco Carriero, Viviana Palmieri, Valentina Palladino, Anna Amoruso, Maria Filomena Gallone, Giovanni C. Del Vecchio, Silvio Tafuri, Giovanna Russo, Federica Valente, Paola Giordano*.

Journal Name: Endocrine, Metabolic & Immune Disorders - Drug Targets
(Formerly Current Drug Targets - Immune, Endocrine & Metabolic Disorders)

Volume 20 , Issue 2 , 2020

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Graphical Abstract:


Objective: Immune thrombocytopenia (ITP) is an acquired immuno-mediated disorder characterized by thrombocytopenia with an increased risk of bleeding. In recent years 1,25[OH]2D3 has been rediscovered as an immune modulator. We decided to evaluate serum Vitamin D levels in a cohort of children with immune thrombocytopenia in order to discover if Vitamin D concentrations may predict ITP duration.

Methods: Thirty children were enrolled in this study (sixteen with chronic ITP and fourteen with newly diagnosed ITP) to assess serum Vitamin D levels.

Results: The results showed that 80% of the enrolled children presented a D hypovitaminosis status. Children with newly diagnosis ITP showed no statistically significantly higher median values of Vitamin D compared to chronic ITP.

Conclusion: This study may suggest that Vitamin D deficiency does not represent a chronicity factor for ITP. However, further studies are needed to understand the role of Vitamin D in ITP pathogenesis.

Keywords: Autoimmunity, children, D vitamin, immune thrombocytopenia, platelets, chronicity.

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Article Details

Year: 2020
Page: [221 - 226]
Pages: 6
DOI: 10.2174/1871530319666190614152709
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