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Current Organic Chemistry

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ISSN (Print): 1385-2728
ISSN (Online): 1875-5348

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Research Article

Synthesis and In Vitro Antitumor Effect of New Vindoline-steroid Hybrids

Author(s): András Keglevich, Vivian Zsiros, Péter Keglevich*, Áron Szigetvári, Miklós Dékány, Csaba Szántay, Erzsébet Mernyák, János Wölfling and László Hazai*

Volume 23, Issue 8, 2019

Page: [959 - 967] Pages: 9

DOI: 10.2174/1385272823666190614113218

open access plus

Abstract

10-Aminovindoline and 17-desacetylvindoline were coupled with 5α- dihydrotestosterone hemisuccinate and 19-nortestosterone hemisuccinate. As a result, four vindoline-steroid hybrids were synthesized via a succinate linker. One of the new hybrid compounds showed significant anticancer effect in vitro in the case of colon cancer and melanoma cell lines.

Keywords: Vinca alkaloids, vindoline, steroid, succinate linker, hybrid molecules, antitumor activity.

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