Dorsal White Matter Integrity and Name Retrieval in Midlife

Author(s): Vanja Kljajevic*, Asier Erramuzpe

Journal Name: Current Aging Science

Volume 12 , Issue 1 , 2019

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Graphical Abstract:


Background: Recent findings on retrieval of proper names in cognitively healthy middle- aged persons indicate that Tip-Of-The-Tongue (TOT) states occurring during proper name retrieval implicate inferior frontal (BA 44) and parietal (BA 40) cortical areas. Such findings give rise to the possibility that anatomical connectivity via dorsal white matter may be associated with difficulties in name retrieval in midlife.

Objectives & Method: Using Diffusion Tensor Imaging, we examined in vivo microstructural properties of white matter in 72 cognitively healthy Middle-Aged (MA) and 59 Young Adults (YA), comparing their naming abilities as well as testing, for possible associations between dorsal white matter integrity and naming abilities in the MA group.

Results: The MA group was better in retrieving correct names (U = 1525.5, p = .006), but they also retrieved more incorrect names than YA believing they had retrieved the correct ones (U = 1265.5, p < .001). Furthermore, despite being more familiar with the tested names than YA (U = 930, p < .001), MA experienced significantly more TOTs relative to YA (U = 1498.5, p = .004). Tract-based spatial statistics showed significant group differences in values of fractional anisotropy (FA), mean diffusivity, axial diffusivity, radial diffusivity, and mode of anisotropy in a range of white matter tracts. In the MA group, FA values in the right Superior Longitudinal Fasciculus (SLF) were positively correlated with “don’t know” scores (rs = .287, p = .014).

Conclusion: The association of SLF integrity and name retrieval ability in midlife indicates a need to revisit the models of name retrieval that posit no role for dorsal white matter in proper name retrieval.

Keywords: Diffusion tensor imaging, white matter, name retrieval, tip-of-the-tongue states, superior longitudinal fasciculus, cortical areas.

Van Langendonck W. Theory and typology of proper names. Berlin: Mouton de Gruyter 2007.
Longobardi G. Toward a unified grammar of reference. Zeitschrift für Sprachwissenschaft 2005; 24: 5-44.
Frege G. On sense and nominatum. 1892/1949.Translated by H.Feigl. In: Feigl H. & Sellars W.,. Readings in philosophical analysis. New York: Appleton-Century Crofts 1949; pp. 85-102.
Mill JS. A system of logic, ratiocinative and inductive, In: Ii-ii, Iiv-v, Iviii, excerpted from: Robson, JM (Ed), The collected works of John Stuart Mill. Toronto: Toronto University Press; 1843/1974.
Russell B. On denoting. Mind 1905; 14: 479-93.
Searle JR. Proper names. Mind 1958; 67: 166-73.
Katz JJ. A proper theory of names. Philos Stud 1977; 31: 1-80.
Kripke S. Naming and necessity. Cambridge, MA: Harvard University Press 1980.
Bartlett FC. Remembering A study in experimental and social psychology. Cambridge: Cambridge University Press 1932/1995..
Burke DM, MacKay DG, Worthley JS, Wade E. On the tip of the tongue: What causes word finding failures young and older adults? J Mem Lang 1991; 30: 542-79.
Cohen G, Burke DM. Memory for proper names: A review. Memory 1993; 1: 249-63.
Damasio H, Grabowski TJ, Tranel D, Hichwa RD, Damasio AR. A neural basis for lexical retrieval. Nature 1996; 380: 499-505.
Brédart S. The cognitive psychology and neuroscience of naming people. Neurosci Biobehav Rev 2017; 83: 145-54.
Semenza C. The neuropsychology of proper names. Mind Lang 2009; 24: 347-69.
Hanley RJ. Why are names of people associated with so many phonological retrieval failures? Psychon Bull Rev 2011; 18: 612-7.
Salthouse TA, Mandell AR. Do age related increases in tip-of-the-tongue experiences signify episodic memory impairments? Psychologic Sci 2013; 24: 2489-97.
James LE, Burke DM. Phonological priming effects on word retrieval and tip-of-the-tongue experiences in young and older adults. J Exp Psychol Learn Mem Cogn 2000; 26: 1378-91.
Schwartz BL, Metcalfe J. Tip-of-the-tongue (TOT) states: Retrieval, behavior, and experience. Mem Cognit 2014; 39: 737-49.
Kljajevic V, Erramuzpe A. Proper name retrieval and structural integrity of cerebral cortex in midlife: A cross-sectional study. Brain Cogn 2018; 120: 26-33.
Huijbers W, Papp KV, LaPoint M, Wigman SF, Dagley A, et al. Age-related increases in tip-of-the-tongue are distinct from decreases in remembering names: A functional MRI study. Cereb Cortex 2017; 27: 4339-49.
Petrides M, Pandya DN. Neural circuitry underlying language.In: Mariën P & Abutalebi J (Eds.),. Neuropsychological Research. NY: Psychology Press 2008; pp. 25-50.
Makris N, Kennedy DN, McInerney S, Sorensen AG, Wang R, Caviness V, et al. Segmentation of subcomponents within the superior longitudinal fascicle in humans: A quantitative, in vivo, DT-MRI study. Cereb Cortex 2005; 15: 854-69.
Papagno C, Miracapillo C, Casarotti A, Romero LJ, Castellano A, Falini A, et al. What is the role of the uncinate fasciculus? Surgical removal and proper name retrieval. Brain 2011; 134: 405-14.
Mehta S, Inoue K, Rudrauf D, Damasio H, Tranel D, Grabowski T. Segregation of anterior temporal regions critical for retrieving names of unique and non/unique entities reflects underlying long-range connectivity. Cortex 2016; 75: 1-19.
Nomura K, Kazui H, Tokunaga H, Hirata M, Goto T, Goto Y, et al. Possible roles of the dominant uncinate fasciculus in naming objects: a case report of intraoperative electrical stimulation on a patient with a brain tumour. Behav Neurol 2013; 27: 229-34.
Duffau H, Moritz-Gasser S, Mandonett E. A re-examination of neural basis of language processing: Proposal of a dynamic hodotopical model from data provided by brain stimulation mapping during picture naming. Brain Lang 2014; 131: 1-10.
Duffau H, Gatinol P, Moritz-Gasser S, Mandonnet E. Is the left uncinate fasciculus essential for language? J Neurol 2009; 256: 382-9.
Basser PJ, Pierpaoli C. Microstructural and physiological features of tissues elucidated by quantitative-diffusion-tensor MRI. J Magn Reson B 1996; 111: 209-19.
Salthouse TA. Neuroanatomical substrates of age-related cognitive decline. Psychol Bull 2011; 137: 753-84.
Salthouse TA. Major issues in cognitive aging. Oxford: Oxford University Press 2010.
Alexander AL, Lee JE, Lazar M, Field AS. Diffusion Tensor Imaging of the Brain. Neurotherapeutics 2007; 4: 316-29.
Douaud G, Jbabdi S, Behrens TE, Menke RA, Gass A, Monsch AU, et al. DTI measures in crossing-fibre areas: Increased diffusion anisotropy reveals early white matter alteration in MCI and mild Alzheimer’s disease. Neuroimage 2011; 55(3): 880-90.
Kljajevic V, Meyer P, Holzmann C. Dyrba M, Kasper E, Bokde AL, Fellgiebel A, et al . The ε4 genotype of Apolipoprotein E and white matter integrity in Alzheimer’s disease. Alzheimers Dement 2014; 10: 401-4.
Beaulieu C. The basis of anisotropic water diffusion in the nervous system- A technical review. NMR Biomed 2002; 15: 435-55.
Benitez A, Fieremans E, Jensen JH, Falangola MF, Tabesh A, Ferris SH, et al. White matter tract integrity metrics reflect the vulnerability of late-myelinating tracts in Alzheimer’s disease. Neuroimage Clin 2014; 4: 64-71.
Kennedy KM, Raz N. Pattern of normal age-related regional differences in white matter microstructure is modified by vascular risk. Brain Res 2009; 1297: 41-56.
Charlton RA, Schiavone F, Barrick TR, Markus HS. Diffusion tensor imaging detects age related white matter change over a 2 year follow-up which is associated with working memory decline. J Neurol Neurosurg Psychiatry 2010; 81: 13-9.
Taylor JR, Williams N, Cusack AT, Auer T, Shafto MA, Dixon M, et al. The cambridge center for ageing and neuroscience (cam-can) data repository: Structural and functional MRI, MEG, and cognitive data. Neuroimage 2015; 144: 262-9.
Shafto MA, Tyler LK, Dixon M, Taylor JR, Rowe JB, Cusack R, et al. The cambridge center for ageing and neuroscience (cam-can) study protocol: A cross-sectional, lifespan, multidisciplinary examination of healthy cognitive ageing. BMC Neurol 2014; 14: 204.
Smith SM, Jenkinson M, Johansen-Berg H, Rueckert D, Nichols TE, Mackay CE, et al. Tract-based spatial statistics: Voxelwise analysis of multi-subject diffusion data. Neuroimage 2006; 31: 1487-505.
Obler L, Rykhlevskaia E, Schnyer D, Clark-Cotton MR, Spiro A, Hyun JM, et al. Bilateral brain regions associated with naming in older adults. Brain Lang 2010; 113: 113-23.
Kier LE, Staib HL, Davis LM, Bronen RA. MR imaging of the temporal stem: Anatomic dissection tractography of the uncinate fasciculus, inferior occipito-frontal fasciculus, and Meyer’s loop of the optic radiation. Am J Neuroradiol 2004; 25: 677-91.
Kljajevic V. White matter architecture of the language network. Transl Neurosci 2014; 5(4): 239-52.
Salthouse TA. When does age-related cognitive decline begin? Neurobiol Aging 2009; 30: 507-14.
Madhavan KM, McQueeny T, Howe SR, Shear P, Szaflarski J. Superior longitudinal fasciculus and language functioning in healthy aging. Brain Res 2014; 1562: 11-22.
Madden DJ, Bennett IJ, Song AW. Cerebral white matter integrity and cognitive aging: Contributions from Diffusion Tensor Imaging. Neuropsychol Rev 2009; 19: 415-35.
Frey S, Campbell JSW, Pike BG, Petrides M. Dissociating the human language pathways with high angular resolution diffusion fiber tractography. J Neurosci 2008; 28(45): 11435-44.
Schmahmann JD, Pandya DN. The complex history of the fronto-occipital fasciculus. J Hist Neurosci 2007; 16: 362-77.
Martino J, Brogna C, Robles SG, Vergani F, Duffau H. Anatomic dissection of the inferior fronto-occipital fasciculus revisited in the lights of brain stimulation data. Cortex 2010; 46: 691-9.
Friederici A. Pathways to language: Fiber tracts in the human brain. Trends Cogn Sci 2009; 13: 175-81.
Thiebaut de SM. Dell’Acqua F, Valabregue R, Catani M. Monkey to human comparative anatomy of the frontal lobe association tracts. Cortex 2012; 48: 22-96.
Bernal B, Altman N. The connectivity of the superior longitudinal fasciculus: A tractography DTI study. Magn Reson Imaging 2010; 28: 217-25.
Pfefferbaum A, Sullivan EV. Increased brain white matter diffusivity in normal adult aging: Relationship to anisotropy and partial voluming. Magn Reson Imaging 2003; 49: 953-61.

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Article Details

Year: 2019
Published on: 24 September, 2019
Page: [55 - 61]
Pages: 7
DOI: 10.2174/1874609812666190614110214

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