Background: Thiazole is a good nucleus owing to its various pharmaceutical
applications. Thiazole containing compounds (thiazoles) have shown various biological activities
like antioxidant, analgesic, antibacterial, anticancer, antiallergic, antihypertensive,
antiinflammatory, antimalarial, antifungal and antipsychotic. The scaffold is present in more than
18 FDA approved drugs and also in more than 70 experimental drugs. Only a few reviews are
available in the literature despite its great medicinal importance. During the course of time, this
scaffold has been studied extensively for its antiviral activities and provided compounds with
activity in the nM range. However, no focused review is available on the compilation of antiviral
activities shown by this scaffold.
Objective: In the present review, we have made an effort to compile antiviral literature of thiazoles
reported from the year 2011 to till date.
Methods: We searched the SciFinder database (excluding patent literature) with keywords like
“antiviral”, “anti-HIV” and “virus”. Further filters were applied for the year of publication and
keywords thiazole, reviews etc. to find relevant literature reported on the antiviral activities of thiazoles.
Results: Nearly, 50 research articles were selected to compile and review the antiviral literature of
thiazoles reported from the year 2011 to till date. Compounds 8, 25, 40, 62, 72, 73, 91, 112, 113,
131, 137, 175, 198, 200, 201 and 213 were reported in the literature with potent antiviral activity
against CVB, SARS, RSV, HCV, HRV, VZV, TMV, FMDV, DENV, YFV, influenza virus, Junin
virus, HIV-1, HSV, VV and EBV, respectively.
Conclusion: There is further scope for the synthesis and evaluation of novel thiazole compounds
by taking the most active compounds as lead structures. In conclusion, this review provides an
overview of antiviral activities of thiazole compounds reported from the year 2011 to till date.