Title:Molecular Allergy Diagnostics as an Adjunct to Conventional Diagnostics in a Secondary Pediatric Referral Center
VOLUME: 13 ISSUE: 1
Author(s):Ole D. Wolthers*
Affiliation:Asthma and Allergy Clinic, Children's Clinic Randers, Randers
Keywords:Allergy, asthma, component resolved diagnosis, eczema, molecular allergy diagnostics, peanut, rhinitis, urticaria.
Abstract:
Background: Several compositions for determination of specific molecular components in
allergens have recently been patented. The role of Molecular Allergy (MA) diagnostics in suspected
IgE mediated allergic conditions is currently debated. Guideline reports have concluded that population-
based studies involving evaluation of the usefulness of MA diagnostics are needed.
Objective: To evaluate the usefulness of MA diagnostics in a secondary pediatric referral center.
Methods: A total of 961 children and adolescents aged 0.2-18.8 (mean 7.0) years was included in a
prospective observational survey. Inclusion criterion was a suspected diagnosis of an IgE mediated
condition based on history and clinical symptoms and signs. If a specific diagnosis could not be reached
from conventional investigations suspected peanut allergy, birch pollen allergy and associated crossreactivity,
insect allergy and triggering allergens for specific immunotherapy were assessed by MA
diagnostics.
Results: Based on conventional work-up a diagnostic conclusion was established in 946 patients
(98.4%). MA diagnostics were performed in 15 individuals (1.6%), 7 girls and 8 boys aged 3.2 to 17.8
(mean 10.6) years. In 8 cases a specific diagnosis was established based on MA diagnostics; in 7 cases
MA diagnostics could not improve diagnosis. MA were most frequently (N = 7 (14%)) used in children
with peanut allergy (N = 50).
Conclusion: Most patients in a secondary pediatric referral center with suspected IgE mediated allergy
can be managed by conventional diagnostic methods. MA diagnostics may be useful in small and selected
subgroups as in patients with suspected peanut allergy, however, may not be helpful in all cases.
