Objective: The objective of this study was to entrap water-insoluble drug itraconazole
into polymer to form drug entrapped nanoparticles by using simple formulation strategy and characterize
them for various in vitro properties.
Method: Itraconazole (ITZ) encapsulated Eudragit E 100 nanoparticles (IEENs) were formulated by
emulsification solvent evaporation technique.
Results: Developed IEENs were evaluated for entrapment efficiency, particle size, polydispersity
index, and drug release profile. It was clear that drug polymer ratio along with homogenization
speed are the factors affecting droplet size of an emulsion. Evaluation was done by HPLC at
263nm. DSC, XRD studies were carried out. The in vitro antifungal study of nanoparticles suggested
that they are more effective in inhibiting growth of Candida albicans.
Conclusion: The results from this study suggest the potential use of IEENs to provide a possible
way of improving solubility and thus oral absorption of Itraconazole. Thus the study concluded that
IEENs have potential to effectively treat the fungal infection.