Introduction: Currently animal venoms are considered a potential source of numerous
bioactive peptides of biochemical and pharmacological interest, such as peptides with antithrombotic,
anticoagulant and antimicrobial activity.
Methods: Such is the case of the venom from the genus Scolopendromorpha, where numerous
PAMs ranging from 2.5 to 4.4 kDa have been purified, they are broad spectrum isolates only of S.
Results: In this study, an antimicrobial peptide (SPC13) of 13 kDa, present in the venom of Scolopendra
polymorpha was purified by electroelution and presented antimicrobial activity against S.
aureus and P. aeruginosa with MIC of 45 and 192.5 μg/ml respectively, as well as bacteriostatic
activity against E. coli at a concentration of 155μg/ml.
Conclusion: Additionally, this peptide has a 20.5% hemolytic activity. A partial sequence of
SPC13 showed 98% identity with the histone H3 reported in S. viridis (GenkBank: DQ222181.1).