Novel 1,3,4-Thiadiazole Linked Amide Derivatives of Pteridone: Synthesis and Study of Anticancer Activities

Author(s): Eeduri R. Devi, Reddymasu Sreenivasulu, Koya P. Rao, Ratnakaram V. Nadh, Malladi Sireesha*

Journal Name: Letters in Organic Chemistry

Volume 17 , Issue 1 , 2020

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Abstract:

Cancer is a second leading cause of death after heart attack, in developing as well as undeveloped countries. It is caused by unregulated growth and metastasis of the abnormal cancer cells. Cancer can be cured by radiation, immunotherapy and chemotherapy, among them; chemotherapy is a good treatment for cancer, in which chemotherapeutic drug is used. The anticancer activity of newly synthesized compounds (13a-j) was carried out on four different types of human cancer cell lines like MCF-7 (breast), A549 (lung), Colo-205 (colon) and A2780 (ovarian) by the MTT method, and compared to etoposide used as a positive control. Among them, compound 13g with electron-withdrawing (3,5-dinitro) group, exhibited more promising activity in all cell lines (MCF-7 = 0.10±0.076 µM, A549 = 0.17±0.039 µM, Colo-205= 0.13±0.022 µM and A2780 = 0.87±0.027µM). This compound may act as lead drug in cancer chemotherapy. In future, this compound can be examined for clinical studies.

Keywords: Pteridone, pralatrexate, triamterene, thiamethoxam, anticancer activity, cancer.

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Article Details

VOLUME: 17
ISSUE: 1
Year: 2020
Page: [54 - 60]
Pages: 7
DOI: 10.2174/1570178616666190528095548
Price: $65

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