Background: Hemocoagulase agkistrodon has been widely used for visceral bleeding,
however, its adverse reaction has not been fully recognized.
Case Report: A 65-year-old female with upper gastrointestinal hemorrhage occurred severe coagulation
disorder during her hospitalization. Transfusion of blood products can not improve coagulation
function. Coagulation parameters returned to normal two days after discontinuation of hemocoagulase
Conclusion: So intravenous administration of hemocoagulase should be cautiously used for the
treatment of gastrointestinal bleeding.