Panitumumab Induced Forearm Panniculitis in Two Women With Metastatic Colon Cancer

Author(s): Ciliberto Domenico, Ierardi Antonella, Caroleo Benedetto, Scalise Luigi, Cimellaro Antonio, Colangelo Lidia, Spaziano Giuseppe, Luca Gallelli*.

Journal Name: Current Drug Safety

Volume 14 , Issue 3 , 2019

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Graphical Abstract:


Abstract:

Background: Panitumumab is an EGFR inhibitor used for the treatment of metastatic colorectal cancer (mCRC), even if its use is related to skin toxicity.

Case Presentation: We report the development of forearm panniculitis in two women during the treatment with Panitumumab (6 mg/Kg intravenous every 2 weeks) + FOLFOX-6 (leucovorin, 5- fluorouracil, and oxaliplatin at higher dosage) for the treatment of mCRC.

Results: In both patients, clinical, laboratory and radiological evaluation documented the presence of a local panniculitis, probably related to panitumumab (Naranjo score: 6). Panatimumab discontinuation and antimicrobial + corticosteroid treatment induced a remission of skin manifestations.

Conclusion: We reported for the first time the development of panniculitis during Panitumumab treatment, and we documented that the treatment with beta-lactams to either fluoroquinolones or oxazolidinone in the presence of corticosteroid improves clinical symptoms in young patients with mCRC, without the development of adverse drug reactions or drug-drug interactions.

Keywords: Panitumumab, panniculitis, adverse drug reaction, EGFR, mCRC, FOLFOX.

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Article Details

VOLUME: 14
ISSUE: 3
Year: 2019
Page: [233 - 237]
Pages: 5
DOI: 10.2174/1574886314666190522094713

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