Ectonucleotidases: Potential Target in Drug Discovery and Development

Author(s): Jamshed Iqbal*

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 19 , Issue 11 , 2019

Become EABM
Become Reviewer
Call for Editor

Al-Rashida, M.; Iqbal, J. Therapeutic potentials of ecto‐nucleoside triphosphate diphosphohydrolase, ecto‐nucleotide pyrophosphatase/phosphodiesterase, ecto‐5′‐nucleotidase, and alkaline phosphatase inhibitors. Med. Res. Rev., 2014, 34(4), 703-743.
Robson, S.C.; Sévigny, J.; Zimmermann, H. The E-NTPDase family of ectonucleotidases: Structure function relationships and pathophysiological significance. Purinergic Signal., 2006, 2(2), 409.
Vandenbeuch, A.; Anderson, C.B.; Parnes, J.; Enjyoji, K.; Robson, S.C.; Finger, T.E.; Kinnamon, S.C. Role of the ectonucleotidase NTPDase2 in taste bud function. Proc. Natl. Acad. Sci. , 2013, 110(36), 14789-14794.
Gillerman, I.; Lecka, J.; Simhaev, L.; Munkonda, M.N.; Fausther, M.; Martín-Satué, M.; Fischer, B. 2-Hexylthio-β, γ-CH2-ATP is an effective and selective NTPDase2 inhibitor. J. Med. Chem., 2014, 57(14), 5919-5934.
Lavoie, E.G.; Fausther, M.; Kauffenstein, G.; Kukulski, F.; Künzli, B.M.; Friess, H.; Sévigny, J. Identification of the ectonucleotidases expressed in mouse, rat, and human langerhans islets: Potential role of NTPDase3 in insulin secretion. Am. J. Physiol. Endocrinol. Metab., 2010, 299(4), E647-E656.
Baroja-Mazo, A.; Barbera-Cremades, M.; Pelegrin, P. The participation of plasma membrane hemichannels to purinergic signaling. Biochim. Biophys. Acta Biomembr., 2013, 1828(1), 79-93.
Leblanc, R.; Peyruchaud, O. New insights into the autotaxin/LPA axis in cancer development and metastasis. Exp. Cell Res., 2015, 333(2), 183-189.
Tsai, S.H.; Takeda, K. Regulation of allergic inflammation by the ectoenzyme E-NPP3 (CD203c) on basophils and mast cells. Semin. Immunopathol., 2016, 38(5), 571-579.
Millán, J.L.; Whyte, M.P. Alkaline phosphatase and hypophosphatasia. Calcif. Tissue Int., 2016, 98(4), 398-416.
Sharma, U.; Pal, D.; Prasad, R. Alkaline phosphatase: An overview. Indian J. Clin. Biochem., 2014, 29(3), 269-278.
Al-Rashida, M.; Qazi, S.U.; Batool, N.; Hameed, A.; Iqbal, J. Ectonucleotidase inhibitors: A patent review (2011-2016). Expert Opin. Ther. Pat., 2017, 27(12), 1291-1304.
Rahimova, R.; Fontanel, S.; Lionne, C.; Jordheim, L.P.; Peyrottes, S.; Chaloin, L. Identification of allosteric inhibitors of the ecto-5′-nucleotidase (CD73) targeting the dimer interface. PLOS Comput. Biol., 2018, 14(1)e1005943
Hassan, S.; Channar, P.A.; Larik, F.A.; Saeed, A.; Shah, H.S.; Lecka, J.; Sévigny, J.; Iqbal, J. Synthesis of new series of (E)-1-(2-(2-(4(dimethylamino) benzylidene) hydrazinyl)-4-methylthiazol-5-yl) ethanone derivatives as Ecto-5ʹ-Nucleotidase Inhibitors. Royal. Soc. Open Sci., 2018, 5180837
Macaev, F.; Boldescu, V.; Sucman, N.; Hassan, S.; Iqbal, J.; Neamtu, M.; Lecka, J.; Sévigny, J.; Prodius, D. Ectonucleotidase inhibitory and redox activity of imidazole-based organic salts and ionic liquids. ChemMedChem, 2018, 13, 2297-2304.
Dumontet, C.; Peyrottes, S.; Rabeson, C.; Cros-Perrial, E.; Géant, P.Y.; Chaloin, L.; Jordheim, L.P. CD73 inhibition by purine cytotoxic nucleoside analogue-based diphosphonates. Eur. J. Med. Chem., 2018, 157, 1051-1055.
Rivera, R.P.; Hassan, S.; Ehlers, P.; Lecka, J.; Sévigny, J.; Rodríguez, E.T.; Iqbal, J.; Langer, P. Chemoselective synthesis and human ecto-5′-nucleotidase inhibitory activity of 2-trifluoromethyl-4,6-diarylquinolines. Chem. Select., 2018, 3, 8587-8592.
Kanwal; Khan, K.M.; Afzal, S.; Salar, U.; Lecka, J.; Sévigny, J.; Iqbal, J. Schiff bases of tryptamine as potent nucleoside triphosphate diphosphohydrolases (ntpdase) inhibitors: Synthesis and in vitro studies. Bioorg. Chem., 2019, 82, 253-266.
Kuhrt, D.; Ejaz, S.A.; Afzal, S.; Khan, S.U.; Lecka, J.; Sévigny, J.; Ehlers, P.; Spannenberg, A.; Iqbal, J.; Langer, P. Chemoselective synthesis and biological evaluation of arylated 2-(Trifluoromethyl) quinolines as nucleotide pyrophosphatase (NPPs) inhibitors. Eur. J. Med. Chem., 2017, 138, 816-829.
Ashraf, A.; Ejaz, S.A.; Rahman, S.U.; Siddiqui, W.A.; Arshad, M.N.; Lecka, J.; Sévigny, J.; Zayed, M.E.M.; Asiri, A.M.; Iqbal, J.; Hartinger, C.G.; Hanif, M. Hybrid compounds from chalcone and 1,2-benzothiazine pharmacophores as selective inhibitors of alkaline phosphatase isozymes. Eur. J. Med. Chem., 2018, 159, 282-291.

promotion: free to download

Rights & PermissionsPrintExport Cite as

Article Details

Year: 2019
Published on: 09 July, 2019
Page: [866 - 869]
Pages: 4
DOI: 10.2174/138955751911190517102116

Article Metrics

PDF: 36