Background: 1-Amidoalkyl-2-naphthols are an attractive group of organic compounds
that can be converted to oxazine heterocycles and aminoalkyl naphthols. The derivatives of 1-
amidoalkyl-2-naphthols have significant biological activities and act as drug candidates.
Methods: 1-Amidoalkyl-2-naphthols were synthesized via the three-component condensation reaction
of 2-naphthol, acetamide/benzamide and various aldehydes in the presence of 10 mol% of adipic
acid as an organocatalyst under solvent-free conditions at 120°C.
Results: A simple, efficient, and operative method for the synthesis of 1-amidoalkyl-2-naphtholes in
the presence of adipic acid as the biodegradable catalyst is introduced. Easy operation, acceptable reaction
times, eco-friendly, availability of starting materials, simple separation of products, and high
yields of products are the significant results of this method.
Conclusion: In this study, 1-amidoalkyl-2-naphthols were synthesized using commercially available
reactants in excellent yields and relatively shorter times. In this process, microwave or ultrasonic
waves were not used to provide energy for the reaction.