Pd-Catalyzed Carbonylation-cyclization of N′-(2-bromophenyl)benzamidines by Chloroform as a CO Precursor for the Synthesis of Quinazolin- 4(3H)-ones

Author(s): Abbasian Sepideh, Kabirifard Hassan*, Mahdavi Mohammad

Journal Name: Letters in Organic Chemistry

Volume 17 , Issue 4 , 2020

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Abstract:

We present an efficient method for the synthesis of quinazolin-4(3H)-ones via Pdcatalyzed carbonylation-cyclization of N′-(2-bromophenyl)benzamidines. Chloroform cleanly generated CO under mild conditions. This method allows for the carbonylation-cyclization of N′-(2- bromophenyl)benzamidines in the presence of Pd(OAc)2 to give quinazolin-4(3H)-ones in good to excellent yields.

Keywords: Quinazolin-4(3H)-one, N′-(2-Bromophenyl)benzamidine, chloroform, palladium acetate, carbonylation, anti-ulcer agents.

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Article Details

VOLUME: 17
ISSUE: 4
Year: 2020
Page: [303 - 308]
Pages: 6
DOI: 10.2174/1570178616666190514085642
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