Abstract
Aminocoumarins are one of the important core structural systems, present in several biologically and medicinally active compounds. Owing to its natural occurrence, potential pharmacological applications and remarkable versatility as a privileged precursor, several proficient synthetic protocols have been reported in the literature over the past years. The presence of an amino group and enamine carbon enhances its chemical reactivity and thus such functionality is repeatedly used for the construction of various fused and simple heterocycles. This review highlights the preparation of different aminocoumarins and their applications for the construction of a variety of five, six and eight membered fused heterocycles.
Keywords: Heterocycles, aminocoumarins, povarov reaction, multicomponent reactions, fused heterocycles, pharmacological activities.
Current Organic Chemistry
Title:Aminocoumarins: A Privileged Precursor for the Synthesis of Fused Heterocycles
Volume: 23 Issue: 9
Author(s): Saigal, Sumbulunnisan Shareef, Habibur Rahman and Md. Musawwer Khan*
Affiliation:
- Department of Chemistry, Aligarh Muslim University, Aligarh, UP, 202002,India
Keywords: Heterocycles, aminocoumarins, povarov reaction, multicomponent reactions, fused heterocycles, pharmacological activities.
Abstract: Aminocoumarins are one of the important core structural systems, present in several biologically and medicinally active compounds. Owing to its natural occurrence, potential pharmacological applications and remarkable versatility as a privileged precursor, several proficient synthetic protocols have been reported in the literature over the past years. The presence of an amino group and enamine carbon enhances its chemical reactivity and thus such functionality is repeatedly used for the construction of various fused and simple heterocycles. This review highlights the preparation of different aminocoumarins and their applications for the construction of a variety of five, six and eight membered fused heterocycles.
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Cite this article as:
Saigal , Shareef Sumbulunnisan , Rahman Habibur and Khan Musawwer Md. *, Aminocoumarins: A Privileged Precursor for the Synthesis of Fused Heterocycles , Current Organic Chemistry 2019; 23 (9) . https://dx.doi.org/10.2174/1385272823666190514073610
DOI https://dx.doi.org/10.2174/1385272823666190514073610 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
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