Aminocoumarins: A Privileged Precursor for the Synthesis of Fused Heterocycles

Author(s): Saigal, Sumbulunnisan Shareef, Habibur Rahman, Md. Musawwer Khan*

Journal Name: Current Organic Chemistry

Volume 23 , Issue 9 , 2019

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Graphical Abstract:


Aminocoumarins are one of the important core structural systems, present in several biologically and medicinally active compounds. Owing to its natural occurrence, potential pharmacological applications and remarkable versatility as a privileged precursor, several proficient synthetic protocols have been reported in the literature over the past years. The presence of an amino group and enamine carbon enhances its chemical reactivity and thus such functionality is repeatedly used for the construction of various fused and simple heterocycles. This review highlights the preparation of different aminocoumarins and their applications for the construction of a variety of five, six and eight membered fused heterocycles.

Keywords: Heterocycles, aminocoumarins, povarov reaction, multicomponent reactions, fused heterocycles, pharmacological activities.

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Article Details

Year: 2019
Page: [1045 - 1075]
Pages: 31
DOI: 10.2174/1385272823666190514073610
Price: $58

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