Background: There is no data available on the best insulin treatment to counteract the effects
of glucose excursions due to a moderate alcohol intake associated with portions of slight fat and
protein-containing food, as often the case during social happenings or “happy hours”.
Introduction: This study analyzes the glycemic control and quality of life in 8 adult type 1 diabetic
(T1D) patients on insulin-pump therapy which were invited to consume a traditional Italian aperitif
(“Spritz” and chips).
Methods: Patients consumed Spritz aperitif twice: using their habitual bolus, based on carbohydrates
(CHO) counting (V1), or with a personalized, advanced bolus (V2) calculated from insulin/Kcal derived
from Fats and Proteins (FPU). Post-prandial glucose was continuously monitored; glucose incremental
areas (iAUC), glucose peak and time to peak, and estimated change from V1 to V2 from repeated-
measures models were computed. Each patient fulfilled validated questionnaires on quality of
life, knowledge about diabetes and CHO counting.
Results: After the educational program, a reduced iAUC (0-80 min: -306, p=ns; 40-80 min: -400,
p=0.07) due to greater (p=0.03) and prolonged double-wave insulin boluses was observed. Blood glucose
peak and time to peak were also reduced. Moreover, improvements in the psycho-affective dimension,
as well as in the alimentary knowledge were detected.
Conclusion: Therefore, a personalized educational program on CHO + FPU counting together with insulin
bolus management can improve glycemic control during social consumption of alcohol, with positive
reflections on the psycho-affective dimension. Further studies are mandatory to confirm such preliminary