Objectives: To study the hemodynamic changes of hepatic & renal vessels in systemic
bacterial infection with fever in HCV related cirrhosis with possible complications.
Methods: Three groups of patients with systemic bacterial infection with fever were included in
the study; group І included 15 patients with decompensated cirrhosis, group ІІ included 15 patients
with compensated cirrhosis and group ІІІ included 10 patients without liver affection. Laboratory
parameters and Doppler US of hepatic and renal vessels were evaluated during and after
subsidence of fever in all patients.
Results: Forty patients were enrolled in this prospective study. There were 22 male and 18 female
patients. We found that the direction of blood flow in the portal and splenic veins was hepatopetal
and the veins were non pulsatile in all cases with no change during and after subsidence of infection.
There was no significant difference in portal or splenic vein diameters during and after subsidence
of infection in the three studied groups. However, the mean values of portal and splenic
veins peak velocities were significantly lower during infection in cirrhotic groups. The mean value
of hepatic artery resistive index during fever was significantly higher than after fever in cirrhotic
groups. Renal resistive and pulsatility indices were significantly higher during fever in cirrhotic
Conclusion: Systemic bacterial infection with fever can affect hepatic haemodynamics leading to
aggravation of portal hypertension and increasing the risk of complications as variceal bleeding
and hepatic encephalopathy and can also affect renal haemodynamics with increased risk of renal