Neuroinflammation in Alzheimer’s Disease: Microglia, Molecular Participants and Therapeutic Choices

Author(s): Haijun Wang, Yin Shen, Haoyu Chuang, Chengdi Chiu, Youfan Ye, Lei Zhao*

Journal Name: Current Alzheimer Research

Volume 16 , Issue 7 , 2019

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Abstract:

Alzheimer’s disease is the world’s most common dementing illness. It is pathologically characterized by β-amyloid accumulation, extracellular senile plaques and intracellular neurofibrillary tangles formation, and neuronal necrosis and apoptosis. Neuroinflammation has been widely recognized as a crucial process that participates in AD pathogenesis. In this review, we briefly summarized the involvement of microglia in the neuroinflammatory process of Alzheimer’s disease. Its roles in the AD onset and progression are also discussed. Numerous molecules, including interleukins, tumor necrosis factor alpha, chemokines, inflammasomes, participate in the complex process of AD-related neuroinflammation and they are selectively discussed in this review. In the end of this paper from an inflammation- related perspective, we discussed some potential therapeutic choices.

Keywords: Alzheimer's disease, neuroinflammation, microglia, beta-amyloid, dementia, chemokinases.

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Article Details

VOLUME: 16
ISSUE: 7
Year: 2019
Page: [659 - 674]
Pages: 16
DOI: 10.2174/1567205016666190503151648
Price: $65

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