Bioinspired Polymeric-based Core-shell Smart Nano-systems

Author(s): Ranjit K. Harwansh, Rohitas Deshmukh, Md Abul Barkat, Md. Akhlaquer Rahman*

Journal Name: Pharmaceutical Nanotechnology

Volume 7 , Issue 3 , 2019


Become EABM
Become Reviewer
Call for Editor

Graphical Abstract:


Abstract:

Smart nanosystems (SNs) have the potential to revolutionize drug delivery. Conventional drug delivery systems have poor drug-loading, early burst release, limited therapeutic effects, etc. Thus, to overcome these problems, researchers have taken advantage of the host-guest interactions as bioinspired nanosystems which can deliver nanocarriers more efficiently with the maximum drug loading capacity and improved therapeutic efficacy as well as bioavailability. SNs employ nanomaterials to form cage molecules by entrapping new nanocarriers called smart nanosystems in their cargo and design. The activities of SNs are based on responsive materials that interact with the stimuli either by changing their properties or conformational structures. The aptitude of living systems to respond to stimuli and process information has encouraged researchers to build up integrated nanosystems exhibiting similar function and therapeutic response. Various smart materials, including polymers, have been exhaustively employed in fabricating different stimuli-responsive nanosystems which can deliver bioactive molecules to a specific site for a certain period with minimal side effects. SNs have been widely explored to deliver diverse kinds of therapeutic agents ranging from bioactive compounds, genes, and biopharmaceuticals like proteins and peptides, to diagnostic imaging agents for biomedical applications. Nanotechnology-based different nanosystems are promising for health care issues. The advancement of SNs with physical science and engineering technology in synthesizing nanostructures and their physicochemical characterization should be exploited in medicine and healthcare for reducing mortality rate, morbidity, disease prevalence and general societal burden.

Keywords: Bio-mimicking nanoparticles, bioinspired approach, core-shell, polymersomes, smart nanosystems, polymeric based.

[1]
Karimi M, Sahandi Zangabad P, Baghaee-Ravari S, et al. Smart nanostructures for cargo delivery: uncaging and activating by light. J Am Chem Soc 2017; 139(13): 4584-610.
[2]
Murday JS, Siegel RW, Stein J, et al. Translational nanomedicine: status assessment and opportunities. Nanomedicine 2009; 5(3): 251-73.
[3]
Pippa N, Merkouraki M, Pispas S, et al. DPPC: MPOx chimeric advanced drug delivery nano systems (chi-aDDnSs): physicochemical and structural characterization, stability and drug release studies. Int J Pharm 2013; 450(1-2): 1-10.
[4]
Chang EH, Harford JB, Eaton MA, et al. Nanomedicine: past, present and future - a global perspective. Biochem Biophys Res Commun 2015; 468(3): 511-7.
[5]
Alvarez-Lorenzo C, Concheiro A. Bioinspired drug delivery systems. Curr Opin Biotechnol 2013; 24: 1-7.
[6]
Kwon EJ, Lo JH, Bhatia SN. Smart nanosystems: bio-inspired technologies that interact with the host environment. Proc Natl Acad Sci USA 2015; 112(47): 14460-6.
[7]
Harisa GI, Badran MM, Alanazi FK, et al. Crosstalk of nanosystems induced extracellular vesicles as promising tools in biomedical applications. J Membr Biol 2017; 250(6): 605-16.
[8]
Pitchaimani A, Nguyen TDT, Aryal S. Natural killer cell membrane infused biomimetic liposomes for targeted tumor therapy. Biomaterials 2018; 160: 124-37.
[9]
P’erez-Mitta G, Albesa AG, Trautmann C, et al. Bioinspired integrated nanosystems based on solid state nanopores: “iontronic” transduction of biological, chemical and physical stimuli. Chem Sci 2017; 8: 890-913.
[10]
Li X, Xie Y, Song B, et al. A stimuli-responsive smart lanthanide nanocomposite for multidimensional optical recording and encryption. Angew Chem Int Ed Engl 2017; 56(10): 2689-93.
[11]
Farshbaf M, Salehi R, Annabi N, et al. pH- and thermo-sensitive MTX-loaded magnetic nanocomposites: synthesis, characterization, and in vitro studies on A549 lung cancer cell and MR imaging. Drug Dev Ind Pharm 2018; 44(3): 452-62.
[12]
El-Sherbiny I, Khalil I, Ali I, et al. Updates on smart polymeric carrier systems for protein delivery. Drug Dev Ind Pharm 2017; 43(10): 1567-83.
[13]
Li Y, Thambi T, Lee DS. Co-delivery of drugs and genes using polymeric nanoparticles for synergistic cancer therapeutic effects. Adv Healthc Mater 2018; 7(1)1700886
[14]
Merkle HP. Drug delivery’s quest for polymers: where are the frontiers? Eur J Pharm Biopharm 2015; 97: 293-303.
[15]
Bangde P, Atale S, Dey A, et al. Potential gene therapy towards treating neurodegenerative diseases employing polymeric nanosystems. Curr Gene Ther 2017; 17(2): 170-83.
[16]
Canfarotta F, Whitcombe MJ, Piletsky SA. Polymeric nanoparticles for optical sensing. Biotechnol Adv 2013; 31: 1585-99.
[17]
Deshayes S, Gref R. Synthetic and bioinspired cage nanoparticles for drug delivery. Nanomedicine 2014; 9(10): 1545-64.
[18]
Cavallaro G, Sardo C, Scialabba C, et al. Smart inulin-based polycationic nanodevices for siRNA delivery. Curr Drug Deliv 2017; 14(2): 224-30.
[19]
Singh R, Lillard JWJ. Nanoparticle-based targeted drug delivery. Exp Mol Pathol 2009; 86: 215-23.
[20]
Mukherjee PK, Harwansh RK, Bhattacharyya S. Bioavailability of herbal products: approach toward improved pharmacokinetics. In: Mukherjee PK, Eds. Evidence- based validation of herbal medicine, Elsevier, Amsterdam, 2015; pp. 217-245.
[21]
Yang Z, Luo X, Zhang X, et al. Targeted delivery of 10-hydroxycamptothecin to human breast cancers by cyclic RGD-modified lipid-polymer hybrid nanoparticles. Biomed Mater 2013; 8025012
[22]
Su X, Wang Z, Li L, et al. Lipid-polymer nanoparticles encapsulating doxorubicin and 2′-deoxy-5-azacytidine enhance the sensitivity of cancer cells to chemical therapeutics. Mol Pharm 2013; 10: 1901-9.
[23]
Zheng Y, Yu B, Weecharangsan W, et al. Transferrin-conjugated lipid-coated PLGA nanoparticles for targeted delivery of aromatase inhibitor 7-alpha-APTADD to breast cancer cells. Int J Pharm 2010; 390: 234-41.
[24]
Tsai MH, Peng CL, Yang SJ, et al. Photothermal, targeting, theranostic near-infrared nano agent with SN38 against colorectal cancer for chemo-thermal therapy. Mol Pharm 2017; 14: 2766-80.
[25]
Gao LY, Liu XY, Chen CJ, et al. Core-shell type lipid/rPAA-Chol polymer hybrid nanoparticles for in vivo siRNA delivery. Biomaterials 2014; 35: 2066-78.
[26]
Copp JA, Fang RH, Luk BT, et al. Clearance of pathological antibodies using biomimetic nanoparticles. Natl Acad Sci USA 2014; 111: 13481-6.
[27]
Ghavami Nejad A, Samari Khalaj M, Aguilar LE, et al. PH/NIR light-controlled multidrug release via a mussel-inspired nanocomposite hydrogel for chemo-photothermal cancer therapy. Sci Rep 2016; 6: 33594.
[28]
Kong SD, Sartor M, Hu CMJ, et al. Magnetic field activated lipid-polymer hybrid nanoparticles for stimuli-responsive drug release. Acta Biomater 2013; 9: 5447-52.
[29]
Kumar SS, Mahesh A, Mahadevan S, et al. Synthesis and characterization of curcumin loaded polymer/lipid based nanoparticles and evaluation of their antitumor effects on MCF-7 cells. Biochim Biophys Acta 2014; 1840: 1913-22.
[30]
Xie J, Yong Y, Dong X, et al. Therapeutic nanoparticles based on curcumin and bamboo charcoal nanoparticles for chemo-photothermal synergistic treatment of cancer and radioprotection of normal cells. ACS Appl Mater Interfaces 2017; 9: 14281-91.
[31]
Fang RH, Hu CM, Chen KN, et al. Lipid-insertion enables targeting functionalization of erythrocyte membrane-cloaked nanoparticles. Nanoscale 2013; 5: 8884-8.
[32]
Liu Y, Li K, Pan J, et al. Folic acid conjugated nanoparticles of mixed lipid monolayer shell and biodegradable polymer core for targeted delivery of Docetaxel. Biomaterials 2010; 31: 330-8.
[33]
Lin CT, Lin IC, Sung SY, et al. Dual-targeted photopenetrative delivery of multiple micelles/hydrophobic drugs by a nanopea for enhanced tumor therapy. Adv Funct Mater 2016; 26: 4169-79.
[34]
Zhu X, Zhang Y, Huang H, et al. Folic acid-modified and functionalized CuS nanocrystal-based nanoparticles for combined tumor chemo- and photothermal therapy. J Drug Target 2017; 25: 425-35.
[35]
Su YL, Chen KT, Sheu YC, et al. The penetrated delivery of drug and energy to tumors by lipo-graphene nanosponges for photolytic therapy. ACS Nano 2016; 10(10): 9420-33.
[36]
Mieszawska AJ, Gianella A, Cormode DP, et al. Engineering of lipid-coated PLGA nanoparticles with a tunable payload of diagnostically active nanocrystals for medical imaging. Chem Commun 2012; 48: 5835-7.
[37]
Gao J, Xia Y, Chen H, et al. Polymer-lipid hybrid nanoparticles conjugated with anti-EGF receptor antibody for targeted drug delivery to hepatocellular carcinoma. Nanomedicine 2014; 9: 279-93.
[38]
Efthimiadou EK, Fragogeorgi E, Palamaris L, et al. Versatile quarto stimuli nanostructure based on trojan horse approach for cancer therapy: synthesis, characterization, in vitro and in vivo studies. Mater Sci Eng C 2017; 79: 605-12.
[39]
Meng X, Liu Z, Cao Y, et al. Fabricating aptamer-conjugated PEGylated-MoS2/Cu1.8S theranostic nanoplatform for multiplexed imaging diagnosis and chemo-photothermal therapy of cancer. Adv Funct Mater 2017; 271605592
[40]
Xi J, Da L, Yang C, et al. Mn2+-Coordinated PDA@DOX/PLGA nanoparticles as a smart theranostic agent for synergistic chemo-photothermal tumor therapy. Int J Nanomedicine 2017; 12: 3331-45.
[41]
Chen H, Ma Y, Wang X, et al. Facile synthesis of prussian blue nanoparticles as pH-responsive drug carriers for combined photothermal-chemo treatment of cancer. RSC Advances 2017; 7: 248-55.
[42]
Lee YH, Chang DS. Fabrication, characterization and biological evaluation of anti-her2 indocyanine green-doxorubicin-encapsulated PEG-b-PLGA copolymeric nanoparticles for targeted photochemotherapy of breast cancer cells. Sci Rep 2017; 7: 46688.
[43]
Chen W, Zeng K, Liu H, et al. Cell membrane camouflaged hollow prussian blue nanoparticles for synergistic photothermal-/chemotherapy of cancer. Adv Funct Mater 2017; 271605795
[44]
Cao Y, Wu Y, Wang G, et al. Near-infrared conjugated polymers for photoacoustic imaging-guided photothermal/chemo combination therapy. J Mater Chem B 2017; 5: 5479-87.
[45]
Zhong T, Fu J, Huang R, et al. Core-shell structured nanospheres for photothermal ablation and pH-triggered drug delivery toward synergistic cancer therapy. RSC Advances 2017; 7: 26640-9.
[46]
Hung CC, Huang WC, Lin YW, et al. Active tumor permeation and uptake of surface charge-switchable theranostic nanoparticles for imaging-guided photothermal/chemo combinatorial therapy. Theranostics 2016; 6: 302-17.
[47]
Dong X, Yin W, Yu J, et al. Mesoporous bamboo charcoal nanoparticles as a new near-infrared responsive drug carrier for imaging-guided chemotherapy/photothermal synergistic therapy of tumor. Adv Healthc Mater 2016; 5: 1627-37.
[48]
Chen C, Syu W, Huang T, et al. Encapsulation of Au/Fe3O4 nanoparticles into a polymer nanoarchitecture with combined near infrared-triggered chemo-photothermal therapy based on intracellular secondary protein understanding. J Mater Chem B 2017; 5: 5774-82.
[49]
Shen S, Ding B, Zhang S, et al. Near-infrared light-responsive nanoparticles with thermosensitive yolk-shell structure for multimodal imaging and chemo-photothermal therapy of tumor. Nanomed Nanotechnol Biol Med 2017; 13: 1607-16.
[50]
Chen Y, Li H, Deng Y, et al. Near-infrared light triggered drug delivery system for higher efficacy of combined chemo-photothermal treatment. Acta Biomater 2017; 51: 374-92.
[51]
Nehate C, Alex MRA, Kumar A, et al. Combinatorial delivery of superparamagnetic iron oxide nanoparticles (gamma Fe2O3) and doxorubicin using folate conjugated redox sensitive multiblock polymeric nanocarriers for enhancing the chemotherapeutic efficacy in cancer cells. Mater Sci Eng C 2017; 75: 1128-43.
[52]
Zhang J, Gong C, Li B, et al. A magnetic polypeptide nanocomposite with pH and near-infrared dual responsiveness for cancer therapy. J Polym Res 2017; 24: 122.
[53]
Lee YH, Ma YT. Synthesis, characterization, and biological verification of anti-HER2 indocyanine green-doxorubicin-loaded polyethyleneimine-coated perfluorocarbon double nanoemulsions for targeted photochemotherapy of breast cancer cells. J Nanobiotechnology 2017; 15: 41.
[54]
Sengupta S, Eavarone D, Capila I, et al. Temporal targeting of tumour cells and neovasculature with a nanoscale delivery system. Nature 2005; 436: 568-72.
[55]
Wong HL, Rauth AM, Bendayan R, et al. In vivo evaluation of a new polymer-lipid hybrid nanoparticle (PLN) formulation of doxorubicin in a murine solid tumor model. J Pharm Biopharm 2007; 65: 300-8.
[56]
Marino P, Preatoni A, Cantoni A, et al. Single-agent chemotherapy versus combination chemotherapy in advanced non-small cell lung cancer: a quality and meta-analysis study. Lung Cancer 1995; 13: 1-12.
[57]
Zheng M, Yue C, Ma Y, et al. Single-step assembly of DOX/ICG loaded lipid--polymer nanoparticles for highly effective chemo-photothermal combination therapy. ACS Nano 2013; 7: 2056-67.
[58]
Zhang P, Li J, Ghazwani M, et al. Effective co-delivery of doxorubicin and dasatinib using a PEG-Fmocnanocarrier for combination cancer chemotherapy. Biomaterials 2015; 67: 104-14.
[59]
Sun J, Liu Y, Chen Y, et al. Doxorubicin delivered by a redox-responsive dasatinib-containing polymeric prodrug carrier for combination therapy. J Control Release 2017; 258: 43-55.
[60]
Prasad P, Shuhendler A, Cai P, et al. Doxorubicin and mitomycin C co-loaded polymer-lipid hybrid nanoparticles inhibit growth of sensitive and multidrug resistant human mammary tumor xenografts. Cancer Lett 2013; 334: 263-73.
[61]
Wang H, Zhao P, Su W, et al. PLGA/polymeric liposome for targeted drug and gene co-delivery. Biomaterials 2010; 31: 8741-8.
[62]
Moreira AF, Dias DR, Costa EC, et al. Thermo- and pH-responsive nano-in-micro particles for combinatorial drug delivery to cancer cells. Eur J Pharm Sci 2017; 104: 42-51.
[63]
Mandal B, Bhattacharjee H, Mittal N, et al. Core-shell-type lipid-polymer hybrid nanoparticles as a drug delivery platform. Nanomedicine 2013; 9(4): 474-91.
[64]
Mandal B, Mittal NK, Balabathula P, et al. Development and in vitro evaluation of core-shell type lipid-polymer hybrid nanoparticles for the delivery of erlotinib in non-small cell lung cancer. Eur J Pharm Sci 2016; 81: 162-71.
[65]
He Y, Su Z, Xue L, et al. Co-delivery of erlotinib and doxorubicin by pH-sensitive charge conversion nanocarrier for synergistic therapy. J Control Release 2016; 229: 80-92.
[66]
Zhou Z, Kennell C, Jafari M, et al. Sequential delivery of erlotinib and doxorubicin for enhanced triple negative Breast cancer treatment using polymeric nanoparticle. Int J Pharm 2017; 530: 300-7.
[67]
Lee JY, Yang H, Yoon IS, et al. Nanocomplexes based on amphiphilic hyaluronic acid derivative and polyethylene glycol-lipid for ginsenoside Rg3 delivery. J Pharm Sci 2014; 103: 3254-62.
[68]
Li Y, Wu H, Yang X, et al. Mitomycin C-soybean phosphatidylcholine complex-loaded self-assembled PEG-lipid-PLA hybrid nanoparticles for targeted drug delivery and dual-controlled drug release. Mol Pharm 2014; 11: 2915-27.
[69]
Dave V, Yadav RB, Kushwaha K, et al. Lipid-polymer hybrid nanoparticles: development and statistical optimization of norfloxacin for topical drug delivery system. Bioact Mater 2017; 2: 269-80.
[70]
Zhao P, Wang H, Yu M, et al. Paclitaxel loaded folic acid targeted nanoparticles of mixed lipid-shell and polymer-core: in vitro and in vivo evaluation. Eur J Pharm Biopharm 2012; 81: 248-56.
[71]
Aravind A, Jeyamohan P, Nair R, et al. AS1411 aptamer tagged PLGA-lecithin-PEG nanoparticles for tumor cell targeting and drug delivery. Biotechnol Bioeng 2012; 109: 2920-31.
[72]
Hu CMJ, Kaushal S, Cao HST, et al. Half-antibody functionalized lipid-polymer hybrid nanoparticles for targeted drug delivery to carcinoembryonic antigen presenting pancreatic cancer cells. Mol Pharm 2010; 7: 914-20.
[73]
Chan JM, Zhang L, Tong R, et al. Spatiotemporal controlled delivery of nanoparticles to injured vasculature. Proc Natl Acad Sci USA 2010; 107: 2213-8.
[74]
Wang Z, Ho PC. Self-assembled core-shell vascular-targeted nanocapsules for temporal antivasculature and anticancer activities. Small 2010; 6: 2576-83.
[75]
Mieszawska AJ, Kim Y, Gianella A, et al. Synthesis of polymer-lipid nanoparticles for image-guided delivery of dual modality therapy. Bioconjug Chem 2013; 24: 1429-34.
[76]
Nguyen HT, Tran TH, Thapa RK, et al. Targeted co-delivery of polypyrrole and rapamycin by trastuzumab-conjugated liposomes for combined chemo-photothermal therapy. Int J Pharm 2017; 527: 61-71.
[77]
Fang DL, Chen Y, Xu B, et al. Development of lipid-shell and polymer core nanoparticles with water-soluble salidroside for anti-cancer therapy. Int J Mol Sci 2014; 15: 3373-88.
[78]
Park J, Wrzesinski SH, Stern E, et al. Combination delivery of TGF-β inhibitor and IL-2 by nanoscale liposomal polymeric gels enhances tumour immunotherapy. Nat Mater 2012; 11: 895-905.
[79]
Zhao R, Li T, Zheng G, et al. Simultaneous inhibition of growth and metastasis of hepatocellular carcinoma by co-delivery of ursolic acid and sorafenib using lactobionic acid modified and pH-sensitive chitosan-conjugated mesoporous silica nanocomplex. Biomaterials 2017; 143: 1-16.
[80]
Prezotti FG, Cury BSF, Evangelista RC. Mucoadhesive beads of gellan gum/pectin intended to controlled delivery of drugs. Carbohydr Polym 2014; 113: 286-95.
[81]
Mikhail AS, Allen C. Block copolymer micelles for delivery of cancer therapy: transport at the whole body, tissue and cellular levels. J Control Release 2009; 138: 214-23.
[82]
Hamaguchi T, Matsumura Y, Suzuki M, et al. NK105, a paclitaxel incorporating micellar nanoparticle formulation, can extend in vivo antitumour activity and reduce the neurotoxicity of paclitaxel. Br J Cancer 2005; 92: 1240-6.
[83]
Dhawan S, Bijesh MB, Haridas V. Polymersomes from hybrid peptide-based bottlebrush homopolymers. Polymer (Guildf) 2018; 138: 218-28.
[84]
Müller LK, Landfester K. Natural liposomes and synthetic polymeric structures for biomedical applications. Biochem Biophys Res Commun 2015; 468(3): 411-8.
[85]
Jain NK, Gupta U. Application of dendrimer-drug complexation in the enhancement of drug solubility and bioavailability. Expert Opin Drug Metab Toxicol 2008; 4: 1035-52.
[86]
Abderrezak A, Bourassa P, Mandeville JS, et al. Dendrimers bind antioxidant polyphenols and cisplatin drug. PLoS One 2012; 7: 1-12.
[87]
John Ł, Janeta M, Szafert S. Designing of macroporous magnetic bioscaffold based on functionalized methacrylate network covered by hydroxyapatites and doped with nano-MgFe2O4 for potential cancer hyperthermia therapy. Mater Sci Eng C Mater Biol Appl 2017; 78: 901-11.
[88]
Leong JY, Lam WH, Ho KW, et al. Advances in fabricating spherical alginate hydrogels with controlled particle designs by ionotropic gelation as encapsulation systems. Particuology 2016; 24: 44-60.
[89]
Wang W, Zhang Y, Liu W. Bioinspired fabrication of high strength hydrogels from non-covalent interactions. Prog Polym Sci 2017; 71: 1-25.
[90]
Liu BR, Chiang HJ, Huang YW, et al. Cellular internalization of quantum dots mediated by cell-penetrating peptides. Pharm Nanotechnol 2013; 1: 151-61.
[91]
Rahman MA, Harwansh R, Mirza MA, et al. Oral lipid based drug delivery system (LBDDS): formulation, characterization and application: a review. Curr Drug Deliv 2011; 8: 1-16.
[92]
Fathi M, Martin A, McClements DJ. Nanoencapsulation of food ingredients using carbohydrate based delivery systems. Trends Food Sci Technol 2014; 39: 18-39.
[93]
Lu S, Guo Z, Xiang Y, et al. Photoelectric frequency response in a bioinspired bacteriorhodopsin/alumina nanochannel hybrid nanosystem. Adv Mater 2016; 28(44): 9851-6.
[94]
Sanna V, Singh CK, Jashari R, et al. Targeted nanoparticles encapsulating (-)-epigallocatechin-3-gallate for prostate cancer prevention and therapy. Sci Rep 2017; 7: 41573.
[95]
Rebelo A, Molpeceres J, Rijo P, et al. Pancreatic cancer therapy review: from classic therapeutic agents to modern nanotechnologies. Curr Drug Metab 2017; 18(4): 346-59.
[96]
Sainz V, Conniot J, Matos AI, et al. Regulatory aspects on nanomedicines. Biochem Biophys Res Commun 2015; 468(3): 504-10.
[97]
Shaunak S. Perspective: dendrimer drugs for infection and inflammation. Biochem Biophys Res Commun 2015; 468(3): 435-41.
[98]
Shin SR, Migliori B, Miccoli B, et al. Electrically driven microengineered bioinspired soft robots. Adv Mater 2018; 30(10)1704189
[99]
Stauffer F, Thielen M, Sauter C, et al. Skin conformal polymer electrodes for clinical ECG and EEG recordings. Adv Healthc Mater 2018; 7(7)e1700994
[100]
Tamrin SH, Majedi FS, Tondar M, et al. Electromagnetic fields and stem cell fate: when physics meets biology. Rev Physiol Biochem Pharmacol 2016; 171: 63-97.
[101]
Zhang N, Li M, Sun X, et al. NIR-responsive cancer cytomembrane-cloaked carrier free nanosystems for highly efficient and self-targeted tumor drug delivery. Biomaterials 2018; 159: 25-36.
[102]
Barkat MA. Nanosuspension-based aloe vera gel of silver sulfadiazine with improved wound healing activity. AAPS PharmSciTech 2017; 18(8): 3274-85.


open access plus

Rights & PermissionsPrintExport Cite as

Article Details

VOLUME: 7
ISSUE: 3
Year: 2019
Published on: 05 August, 2019
Page: [181 - 205]
Pages: 25
DOI: 10.2174/2211738507666190429104550

Article Metrics

PDF: 32
HTML: 7