A Study of Prescription Pattern and Compliance of Anti-hypertensives with the Treatment Guidelines in Aseer Region; Saudi Arabia

Author(s): Ayesha Siddiqua*, Afaf Alshehri, Amal M. Alahmari, Rawan A. Alshehri, Somayh S. Badawy

Journal Name: Current Drug Therapy

Volume 14 , Issue 3 , 2019

Become EABM
Become Reviewer

Graphical Abstract:


Abstract:

Background: A prescription study is an effective method to evaluate irrational prescribing practice. Hypertension is one such major chronic disease. Compliance to guidelines like the JNC-8 (Eighth Joint National Committee) and Saudi Hypertension guidelines is highly recommended to prevent future complications.

Objective: We conducted this study to assess prescribing pattern and their compliance with the guidelines in the patients.

Methods: A Retrospective cross-sectional study was carried out for 7 weeks in 2017 in Aseer region, Abha, Saudi Arabia on 122 outpatient prescriptions which were included by Non-probability convenience sampling technique. Data from patients aged above 18 years with any stage of Hypertension with or without Diabetes Mellitus was collected.

Results: It was found that Angiotensin converting enzyme inhibitors were frequently prescribed as monotherapy in patients with Hypertension with or without Diabetes Mellitus which is in compliance to the guidelines. Beta-blockers were most commonly used in 2 and 3 drug therapy of patients with only Hypertension which was not in accordance with the guidelines.

Conclusion: By this it could be concluded that the Prescription pattern of Antihypertensive in Aseer Region was in compliance with both the guidelines to a partial extent. Though most of the prescriptions were rational, further improvement was required. Studies that focus on demographic data, economic status, associated conditions and complications would give additional insights into prescribing patterns in hypertension.

Keywords: Prescription pattern, rational prescribing, hypertension, treatment guidelines, compliance, irrational prescribing.

[1]
Yuen Y, Chang S, Chong C, Lee S, Critchlev J, Chan J. Drug utilization in a hospital general medical outpatient clinic with particular reference to antihypertensive and antidiabetic drugs. J Clin Pharm Ther 1998; 23: 287-94.
[2]
Beg MA, Dutta S, Varma A, et al. Study on drug prescribing pattern in hypertensive patients in a tertiary care teaching hospital at Dehradun, Uttarakhand. Int J Med Sci Public Health 2014; 3: 922-6.
[3]
Collins R, Peto R, MacMahon S, et al. Blood pressure, stroke and coronary heart disease. Short term reductions in blood pressure: overview of randomized drug trial in their epidemiological context. Lancet 1990; 335: 827-38.
[4]
Hansson L. The benefits of lowering elevated blood pressure: a critical review of studies of cardiovascular morbidity and mortality in hypertension. J Hypertens 1996; 14: 537-44.
[5]
Al-Nozha MM, Abdullah M, Arafah MR, et al. Hypertension in Saudi Arabia. Saudi Med J 2007; 28(1): 77-84.
[6]
Gupta N, Sharma D, Garg SK, Bhargava VK. Auditing of prescriptions to study utilization of antimicrobials in tertiary hospital. Indian J Pharmacol 1997; 29: 411-5.
[7]
Murti K, Khan MA, Dey A, Sethi MK, Das P, Pandey K. Prescription pattern of anti-hypertensive drugs in adherence to JNC-7 guidelines. Am J Pharmacol Toxicol 2015; 10(1): 27-31.
[8]
Bakare OQ, Akinyinka MR, Goodman O, et al. Antihypertensive use, prescription patterns, and cost of medications in a Teaching Hospital in Lagos, Nigeria. Niger J Clin Pract 2016; 19: 668-72.
[9]
Bipin BP, Manas RP, Pratap KS. Survey of prescription pattern of antihypertensive drugs in hypertensive and diabetic hypertensive patients. Asian J Pharm Clin Res 2015; 8(1): 250-2.
[10]
Gabriel T, Shukrala F. Assessment of prescribing, dispensing, and patient use pattern of antihypertensive drugs for patients attending outpatient department of Hiwot Fana Specialized University Hospital, Harar, Eastern Ethiopia. Drug Des Devel Ther 2015; 9: 519-23.
[11]
Jarari N, Rao N, Peela JR, et al. A review on prescribing patterns of antihypertensive drugs. Clin Hypertens 2015; 22: 7.
[12]
Statistical Year book. Saudi Arabia: Minsitry of health; 2016.
[13]
Jhaj R, Goel NK, Gautam CS, et al. Prescribing patterns and cost of antihypertensive drugs in an internal medicine clinic. Indian Heart J 2001; 53(3): 323-7.
[14]
Malhotra S, Karan RS, Pandhi P, Jain S. Pattern of use and pharmacoeconomic impact of antihypertensive drugs in a North Indian referral hospital. Eur J Clin Pharmacol 2001; 57(6-7): 535-40.


open access plus

Rights & PermissionsPrintExport Cite as

Article Details

VOLUME: 14
ISSUE: 3
Year: 2019
Page: [261 - 266]
Pages: 6
DOI: 10.2174/1574885514666190424155014

Article Metrics

PDF: 16
HTML: 3