Background: Anchomanes difformis (ENGL: Blume) is a specie of flowering plants in
the family Araceae. Anchomanes difformis is commonly reported for ameliorating hyperglycemia,
inflammation, ulcer, malaria, and inhibiting microbial growth.
Objective: This study evaluated total yields of phytochemicals present, measured antioxidant capacities
and identified bioactive compounds in the leaves and rhizome extracts of A. difformis using solvents
of different polarity (ethyl acetate, ethanol and water).
Methods: Total polyphenolic, flavonoid content and alkaloids were measured, ORAC, TEAC and
FRAP were performed as antioxidant capacity indices, and identification of bioactive compounds
was done using UPLC-MS and HPLC.
Results: All extracts contained polyphenols, flavonols, flavanols, and alkaloids in varying concentrations.
All extracts exhibited antioxidant properties. However, aqueous leaves extract had the
highest antioxidant properties and polyphenols with significance (p<0.05). Thirty-four compounds
were identified altogether in the leaves and rhizome.
Conclusion: A. difformis leaves and rhizome are potential sources of natural antioxidants and can
serve as potential therapeutic agents against diseases linked with oxidative stress. Presence of
health-promoting compounds indicates possible ameliorative potentials of A. difformis.