With regard to the importance of quinazoline as a privileged scaffold, herein we report the
synthesis of twenty seven 2,4-disubstitute quinazoline derivatives in a new catalyst free condition. In
the current work, poly ethylene glycol (PEG1000) as an inexpensive, very simple commercially available,
ecofriendly and low melting point solvent was used. Air bubbling, a green oxidant, for oxidation
purpose was also used. This is the first report about using PEG1000 as a solvent simultaneously with
air bubbling as oxidant in quinazoline synthesis. All of the compounds 1-27 were synthesized in high
yield with very simple work up and purification process without using column chromatography. All the
structures were confirmed using 1H NMR, 13C NMR, IR, MS and elemental analysis.
Keywords: Air oxidation, catalyst free, ecofriendly solvent, PEG1000, quinazoline, synthesis.
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