Title:Perivascular Adipose Tissue Oxidative Stress on the Pathophysiology of Cardiometabolic Diseases
VOLUME: 16 ISSUE: 3
Author(s):Jamaira A. Victorio and Ana P. Davel*
Affiliation:Department of Structural and Functional Biology, Institute of Biology, University of Campinas, Campinas-SP, Department of Structural and Functional Biology, Institute of Biology, University of Campinas, Campinas-SP
Keywords:Perivascular adipose tissue (PVAT), oxidative stress, vascular dysfunction, cardiometabolic risk factors, reactive
oxygen species (ROS), cardiometabolic diseases.
Abstract:Most of the systemic blood vessels are surrounded by the perivascular adipose tissue
(PVAT). Healthy PVAT is anticontractile and anti-inflammatory, but a dysfunctional PVAT has
been suggested to link cardiometabolic risk factors to vascular dysfunction. Vascular oxidative
stress is an important pathophysiological event in cardiometabolic complications of obesity, type 2
diabetes, and hypertension. PVAT-derived adipocytes generate reactive oxygen species (ROS) including
superoxide anion and hydrogen peroxide that might signal to the vascular wall. Therefore,
an abnormal generation of ROS by PVAT emerges as a potential pathophysiological mechanism
underlying vascular injury. This review summarizes new findings describing ROS production in the
PVAT of several vascular beds, major sources of ROS in this tissue including mitochondria,
NADPH oxidase and eNOS uncoupled, and finally, changes in ROS production affecting vascular
function in the presence of cardiometabolic risk factors and diseases.
