Recent Advances in Apoptosis: THE Role of Hydrazones

Author(s): Pelin Çıkla-Süzgün, Ş. Güniz Küçükgüzel*

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 19 , Issue 17 , 2019

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Graphical Abstract:


The process of programmed cell death in higher eukaryotes (apoptosis), is generally characterized by distinct morphological characteristics and energy-dependent biochemical mechanisms. Apoptosis is considered as a vital component of various processes including normal cell turnover, proper development and functioning of the immune system, hormone-dependent atrophy, embryonic development and chemical-induced cell death. Apoptosis seems to play an important key role in the progression of several human diseases like Alzheimer's disease, Parkinson's disease and many types of cancer. Promotion of apoptosis may be a good approach for the prevention of cancer cell proliferation. In early studies, antitumor compounds have been found to induce the apoptotic process in tumor cells. On the other hand, several hydrazones were reported to have lower toxicity than hydrazides due to the blockage of –NH2 group. Therefore, the design of hydrazones that activate and promote apoptosis is an attractive strategy for the discovery and development of potential anticancer agents. The aim of this review is to provide a general overview of current knowledge and the connection between apoptosis and hydrazone. It is also the guide for the apoptotic activities of new hydrazone derivatives.

Keywords: Apoptosis, hydrazone, cancer, caspase-8, caspase-3, Bcl-2.

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Year: 2019
Published on: 10 April, 2019
Page: [1427 - 1442]
Pages: 16
DOI: 10.2174/1389557519666190410125910
Price: $65

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