Analgesic and Anti-inflammatory Effects of Caryocar brasiliense

Author(s): Armando Jorge Junior, Maicon Matos Leitão, Laura Priscila Toledo Bernal, Elisângela dos Santos, Ângela Midori Kuraoka-Oliveira, Priscila Justi, Eliana Janet Sanjinez Argandoña, Cândida Aparecida Leite Kassuya*

Journal Name: Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry
Formerly Current Medicinal Chemistry - Anti-Inflammatory & Anti-Allergy Agents

Volume 19 , Issue 3 , 2020


Become EABM
Become Reviewer
Call for Editor

Graphical Abstract:


Abstract:

Background: Caryocar brasiliense, popularly known as pequi, is widely distributed in the Amazon rainforest and Brazilian savannah. The fruit obtained from pequi is used in cooking and has folk use as an anti-inflammatory and for the treatment of respiratory disease. Until now, these two properties had not been scientifically demonstrated for Pequi oil in a carrageenan model.

Objective: Our group determined the composition and safe use of Pequi oil from the Savannah of Campo Grande, and the anti-inflammatory and anti-nociceptive activities of this pequi oil were investigated in vivo models.

Materials and Methods: Doses of 300, 700, and 1000 mg/kg of Pequi oil were administered orally (p.o.) to Swiss male mice, and three parameters of inflammation (mechanical hyperalgesia, cold, hyperalgesia, and oedema) were analyzed in a carrageenan model to induce an inflammatory paw state.

Results and Discussion: The effects of Pequi oil were also carrageenan in pleurisy model, formalin, and acetic acid induced nociception. Oral administration of 1,000 mg/kg orally Pequi oil (p.o.) inhibited (*P<0.05), the migration of total leukocytes, but not alter plasma extravasation, in the pleurisy model when compared to control groups. The paw edema was inhibited with doses of 700 (P <0.05) and 1,000 mg (P<0.001) of pequi oil after 1, 2, and 4 hours after carrageenan. Pequi oil (1,000 mg/kg) also blocked the mechanical hyperalgesy and reduced cold allodynia induced by carrageenan in paw (P <0.05). Pequi oil treatment (1,000 mg/kg) almost blocked (P < 0.001) all parameters of nociception observed in formalin and acid acetic test.

Conclusion: This is the first time that the analgesic and anti-inflammatory effects of Pequi oil have been shown.

Keywords: Anti-edematogenic, anti-hyperalgesic, anti-inflammatory activity, Caryocar brasiliense, antinociceptive, pequi oil.

[1]
Zhang, K.; Zeng, X.; Chen, Y.; Zhao, R.; Wang, H.; Wu, J. Therapeutic effects of Qian-Yu decoction and its three extracts on carrageenan-induced chronic prostatitis/chronic pelvic pain syndrome in rats. BMC Complement. Altern. Med., 2017, 17(1), 75.
[http://dx.doi.org/10.1186/s12906-016-1553-7 ] [PMID: 28122556]
[2]
Guedes, A.M.M.; Antoniassi, R.; Galdeano, M.C.; Grimaldi, R.; Carvalho, M.G.; Wilhelm, A.E.; Marangoni, A.G. Length-scale specific crystalline structural changes induced by molecular randomization of pequi oil. J. Oleo Sci., 2017, 66(5), 469-478.
[http://dx.doi.org/10.5650/jos.ess16192 ] [PMID: 28413191]
[3]
Pinto, L.C.; Morais, L.M.; Guimarães, A.Q.; Almada, E.D.; Barbosa, P.M.; Drumond, M.A. Traditional knowledge and uses of the Caryocar brasiliense Cambess. (Pequi) by “quilombolas” of Minas Gerais, Brazil: subsidies for sustainable management. Braz. J. Biol., 2016, 76(2), 511-519.
[http://dx.doi.org/10.1590/1519-6984.22914 ] [PMID: 27058602]
[4]
Oliveira, L.G.; Moreno, L.G.; Melo, D.S.; Costa-Pereira, L.V.; Carvalho, M.M.; Silva, P.H.; Alves, A.M.; Magalhães, F.C.; Dias-Peixoto, M.F.; Esteves, E.A. Caryocar brasiliense oil improves cardiac function by increasing Serca2a/PLB ratio despite no significant changes in cardiovascular risk factors in rats. Lipids Health Dis., 2017, 16(1), 37.
[http://dx.doi.org/10.1186/s12944-017-0422-9 ] [PMID: 28179001]
[5]
Colombo, N.B.; Rangel, M.P.; Martins, V.; Hage, M.; Gelain, D.P.; Barbeiro, D.F.; Grisolia, C.K.; Parra, E.R.; Capelozzi, V.L. Caryocar brasiliense camb protects against genomic and oxidative damage in urethane-induced lung carcinogenesis. Braz. J. Med. Biol. Res., 2015, 48(9), 852-862.
[http://dx.doi.org/10.1590/1414-431x20154467 ] [PMID: 26200231]
[6]
Amaral, L.F.; Moriel, P.; Foglio, M.A.; Mazzola, P.G. Evaluation of the cytotoxicity and phototoxicity of Caryocar brasiliense supercritical carbon dioxide extract. BMC Complement. Altern. Med., 2014, 14, 450.
[http://dx.doi.org/10.1186/1472-6882-14-450 ] [PMID: 25407631]
[7]
Roesler, R.; Catharino, R.R.; Malta, L.G.; Eberlin, M.N.; Pastore, G. Antioxidant activity of Caryocar brasiliense (pequi) and characterization of components by electrospray ionization mass spectrometry. Food Chem., 2008, 110(3), 711-717.
[http://dx.doi.org/10.1016/j.foodchem.2008.02.048]
[8]
a) Traesel, G.K.; de Araújo, F.H.S.; Castro, L.H.A.; de Lima, F.F.; Menegati, S.E.L.T.; Justi, P.N.; Kassuya, C.A.L.; Cardoso, C.A.L.; Argandoña, E.J.S.; Oesterreich, S.A. Safety assessment of oil from Pequi (Caryocar brasiliense Camb.): evaluation of the potential genotoxic and clastogenic effects. J. Med. Food, 2017, 20(8), 804-811.
[http://dx.doi.org/10.1089/jmf.2017.0021 ] [PMID: 28557544]
[9]
b) Traesel, G. K; de Lima, F. F.; Dos Santos, A.C. Evaluation of embryotoxic and teratogenic effects of the oil extracted from Caryocar brasiliense Cambess pulp in rats. Food Chem. Toxicol., 2017, 110, 74-82.
[http://dx.doi.org/10.1016/j.fct.2017.10.018]
[10]
Torres, L.R.; Santana, F.C.; Torres-Leal, F.L.; Melo, I.L.; Yoshime, L.T.; Matos-Neto, E.M.; Seelaender, M.C.; Araújo, C.M.; Cogliati, B.; Mancini-Filho, J. Pequi (Caryocar brasiliense Camb.) almond oil attenuates carbon tetrachloride-induced acute hepatic injury in rats: antioxidant and anti-inflammatory effects. Food Chem. Toxicol., 2016, 97, 205-216.
[http://dx.doi.org/10.1016/j.fct.2016.09.009 ] [PMID: 27623180]
[11]
Rodriguez-Amaya, D.B. Institute, I.L.S. OMNI, A. Guide to Carotenoid Analysis in Foods; ILSI Press, 2001.
[12]
Di Rosa, M.; Giroud, J.P.; Willoughby, D.A. Studies on the mediators of the acute inflammatory response induced in rats in different sites by carrageenan and turpentine. J. Pathol., 1971, 104(1), 15-29.
[http://dx.doi.org/10.1002/path.1711040103 ] [PMID: 4398139]
[13]
Vinegar, R.; Truax, J.F.; Selph, J.L. Some quantitative temporal characteristics of carrageenin-induced pleurisy in the rat. Proc. Soc. Exp. Biol. Med., 1973, 143(3), 711-714.
[http://dx.doi.org/10.3181/00379727-143-37397 ] [PMID: 4719457]
[14]
Trevizan, L.N.F.; Nascimento, K.F.D.; Santos, J.A.; Kassuya, C.A.L.; Cardoso, C.A.L.; Vieira, M.D.C.; Moreira, F.M.F.; Croda, J.; Formagio, A.S.N. Anti-inflammatory, antioxidant and anti-Mycobacterium tuberculosis activity of viridiflorol: the major constituent of Allophylus edulis (A. St.-Hil., A. Juss. & Cambess.). Radlk. J. Ethnopharmacol., 2016, 192, 510-515.
[http://dx.doi.org/10.1016/j.jep.2016.08.053 ] [PMID: 27612433]
[15]
Bradford, L.W. Problems of ethics and behavior in the forensic sciences. J. Forensic Sci., 1976, 21(4), 763-768.
[http://dx.doi.org/10.1520/JFS10557J ] [PMID: 972302]
[16]
Winter, C.A.; Risley, E.A.; Nuss, G.W. Carrageenin-induced edema in hind paw of the rat as an assay for antiiflammatory drugs. Proc. Soc. Exp. Biol. Med., 1962, 111, 544-547.
[http://dx.doi.org/10.3181/00379727-111-27849 ] [PMID: 14001233]
[17]
Nicotra, L.; Tuke, J.; Grace, P.M.; Rolan, P.E.; Hutchinson, M.R. Sex differences in mechanical allodynia: how can it be preclinically quantified and analyzed? Front. Behav. Neurosci., 2014, 8, 40.
[http://dx.doi.org/10.3389/fnbeh.2014.00040 ] [PMID: 24592221]
[18]
Choi, Y.; Yoon, Y.W.; Na, H.S.; Kim, S.H.; Chung, J.M. Behavioral signs of ongoing pain and cold allodynia in a rat model of neuropathic pain. Pain, 1994, 59(3), 369-376.
[http://dx.doi.org/10.1016/0304-3959(94)90023-X ] [PMID: 7708411]
[19]
Hunskaar, S.; Hole, K. The formalin test in mice: dissociation between inflammatory and non-inflammatory pain. Pain, 1987, 30(1), 103-114.
[http://dx.doi.org/10.1016/0304-3959(87)90088-1 ] [PMID: 3614974]
[20]
Collier, H.O.; Dinneen, L.C.; Johnson, C.A.; Schneider, C. The abdominal constriction response and its suppression by analgesic drugs in the mouse. Br. J. Pharmacol. Chemother., 1968, 32(2), 295-310.
[http://dx.doi.org/10.1111/j.1476-5381.1968.tb00973.x ] [PMID: 4230818]
[21]
Danneman, P.J. Monitoring of Analgesia A2 - Kohn, Dennis F. Anesthesia and Analgesia in Laboratory Animals; Wixson, S.K.; White, W.J; Benson, G.J., Ed.; Academic Press: San Diego, 1997, pp. 83-103.
[http://dx.doi.org/10.1016/B978-012417570-9/50009-X]
[22]
Cabrini, D.A.; Moresco, H.H.; Imazu, P.; da Silva, C.D.; Pietrovski, E.F.; Mendes, D.A.; da Silveira Prudente, A.; Pizzolatti, M.G.; Brighente, I.M.; Otuki, M.F. Analysis of the potential topical anti-inflammatory activity of Averrhoa carambola L. in mice. Evid. Based Complement. Alternat. Med., 2011, 2011, 908059.
[http://dx.doi.org/10.1093/ecam/neq026 ] [PMID: 21785638]
[23]
Aguilar, E.C.; Jascolka, T.L.; Teixeira, L.G.; Lages, P.C.; Ribeiro, A.C.; Vieira, E.L.; Peluzio, M.C.; Alvarez-Leite, J.I. Paradoxical effect of a pequi oil-rich diet on the development of atherosclerosis: balance between antioxidant and hyperlipidemic properties. Braz. J. Med. Biol. Res., 2012, 45(7), 601-609.
[http://dx.doi.org/10.1590/S0100-879X2012007500074 ] [PMID: 22570088]
[24]
Cunha, T.M.; Roman-Campos, D.; Lotufo, C.M.; Duarte, H.L.; Souza, G.R.; Verri, W.A., Jr; Funez, M.I.; Dias, Q.M.; Schivo, I.R.; Domingues, A.C.; Sachs, D.; Chiavegatto, S.; Teixeira, M.M.; Hothersall, J.S.; Cruz, J.S.; Cunha, F.Q.; Ferreira, S.H. Morphine peripheral analgesia depends on activation of the PI3Kgamma/AKT/nNOS/NO/KATP signaling pathway. Proc. Natl. Acad. Sci. USA, 2010, 107(9), 4442-4447.
[http://dx.doi.org/10.1073/pnas.0914733107 ] [PMID: 20147620]
[25]
Miranda-Vilela, A.L.; Ribeiro, I.F.; Grisolia, C.K. Association between interleukin 6 -174 G/C promoter gene polymorphism and runners’ responses to the dietary ingestion of antioxidant supplementation based on pequi (Caryocar brasiliense Camb.) oil: a before-after study. Genet. Mol. Biol., 2016, 39(4), 554-566.
[http://dx.doi.org/10.1590/1678-4685-gmb-2015-0299 ] [PMID: 27727360]
[26]
de Oliveira, F.F.; de Araújo, J.C.; Pereira, A.F.; Brito, G.A.; Gondim, D.V. Ribeiro, Rde.A.; de Menezes, I.R.; Vale, M.L. Antinociceptive and anti-inflammatory effects of Caryocar coriaceum Wittm fruit pulp fixed ethyl acetate extract on zymosan-induced arthritis in rats. J. Ethnopharmacol., 2015, 174, 452-463.
[http://dx.doi.org/10.1016/j.jep.2015.08.017 ] [PMID: 26341615]
[27]
Lima, A.d.; Silva, A.M.O.e.; Trindade, R.A.; Torres, R.P.; Mancini-Filho, J. Composição química e compostos bioativos presentes na polpa e na amêndoa do pequi (Caryocar brasiliense, Camb.). Rev. Bras. Frutic., 2007, 29, 695-698.
[http://dx.doi.org/10.1590/S0100-29452007000300052]
[28]
Saraiva, R.A.; Araruna, M.K.; Oliveira, R.C.; Menezes, K.D.; Leite, G.O.; Kerntopf, M.R.; Costa, J.G.; Rocha, J.B.; Tomé, A.R.; Campos, A.R.; Menezes, I.R. Topical anti-inflammatory effect of Caryocar coriaceum Wittm. (Caryocaraceae) fruit pulp fixed oil on mice ear edema induced by different irritant agents. J. Ethnopharmacol., 2011, 136(3), 504-510.
[http://dx.doi.org/10.1016/j.jep.2010.07.002 ] [PMID: 20621180]
[29]
Perini, J.A.D.L.; Stevanato, F.B.; Sargi, S.C.; Visentainer, J.E.L.; Dalalio, M.M.D.O.; Matshushita, M.; Souza, N.E.D.; Visentainer, J.V. Ácidos graxos poli-insaturados n-3 e n-6: metabolismo em mamíferos e resposta imune. Rev. Nutr., 2010, 23, 1075-1086.
[http://dx.doi.org/10.1590/S1415-52732010000600013]
[30]
Cordeiro, M.W.S.; Cavallieri, Â.L.F.; Ferri, P.H.; Naves, M.M.V. Características físicas, composição químico-nutricional e dos óleos essenciais da polpa de Caryocar brasiliense nativo do estado de Mato Grosso. Rev. Bras. Frutic., 2013, 35, 1127-1139.
[http://dx.doi.org/10.1590/S0100-29452013000400024]
[31]
Amaral, L.F.; Moriel, P.; Foglio, M.A.; Mazzola, P.G. Caryocar brasiliense supercritical CO2 extract possesses antimicrobial and antioxidant properties useful for personal care products. BMC Complement. Altern. Med., 2014, 14, 73.
[http://dx.doi.org/10.1186/1472-6882-14-73] [PMID: 24565304]


open access plus

Rights & PermissionsPrintExport Cite as

Article Details

VOLUME: 19
ISSUE: 3
Year: 2020
Published on: 02 September, 2020
Page: [313 - 322]
Pages: 10
DOI: 10.2174/1871523018666190408144320

Article Metrics

PDF: 42
HTML: 1