Background: Bacteria communicate by producing small signaling molecules to maintain
threshold cell density. Quorum sensing inhibition is an effective and most potent approach for the prevention
of cell to cell communication.
Methods: In the present study, the methanol extract of Garcinia indica was tested for anti-quorum sensing
activity using Chromobacterium violaceum as a biosensor. The extract inhibited violacein production
in biosensor strain without affecting the growth of the bacteria and this was corroborated by
Results: The bioactive fraction was analysed by the aid of GC-MS revealed that, the presence of coumarin
(7-hydroxy-3-(1,1-dimethylprop-2-enyl) coumarin) and eugenol (1,2-dimethoxy-4-(1-methoxy-1-
propenyl) benzene) derivatives as anti-quorum sensing molecules.
Conclusion: A detailed investigation is required to study the mechanism of action involved in control
of quorum sensing signals and possible applications.